<div id="readability-page-1"><p>Assenagon Asset Management S.A. lowered its position in shares of  Protagonist Therapeutics, Inc. (NASDAQ:PTGX - Free Report) by 28.4% in the third quarter, according to the company in its most recent Form 13F filing with the Securities and Exchange Commission. The institutional investor  owned 65,756 shares of the company's stock after selling 26,119 shares during the period. Assenagon Asset Management S.A. owned 0.11% of Protagonist Therapeutics worth $4,368,000 at the end of the most recent quarter.</p><ul><li>Johnson &amp; Johnson's M&amp;A Strategy Is the Real Story for Investors</li></ul><p>A number of other hedge funds and other institutional investors also recently bought and sold shares of the business. Guggenheim Capital LLC boosted its position in shares of  Protagonist Therapeutics by 1.6% during the 2nd quarter. Guggenheim Capital LLC now owns 19,208 shares of the company's stock worth $1,062,000 after acquiring an additional 303 shares in the last quarter.  Bessemer Group Inc. lifted its stake in  Protagonist Therapeutics by 171.0% during the second quarter. Bessemer Group Inc. now owns 504 shares of the company's stock worth $28,000 after purchasing an additional 318 shares during the last quarter.  Hsbc Holdings PLC lifted its stake in  Protagonist Therapeutics by 4.1% during the first quarter. Hsbc Holdings PLC now owns 8,458 shares of the company's stock worth $405,000 after purchasing an additional 330 shares during the last quarter.  Mirae Asset Global Investments Co. Ltd. boosted its holdings in  Protagonist Therapeutics by 16.6% in the second quarter. Mirae Asset Global Investments Co. Ltd. now owns 2,394 shares of the company's stock valued at $132,000 after purchasing an additional 340 shares in the last quarter.  Finally, MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. increased its stake in  Protagonist Therapeutics by 0.9% in the first quarter. MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. now owns 37,403 shares of the company's stock valued at $1,810,000 after purchasing an additional 348 shares during the last quarter. 98.63% of the stock is currently owned by institutional investors and hedge funds. </p><h2>Insider Buying and Selling at Protagonist Therapeutics</h2><p>In other Protagonist Therapeutics news, Director William D. Waddill sold 12,000 shares of Protagonist Therapeutics stock in a transaction that occurred on Friday, October 10th. The stock was sold at an average price of $81.62, for a total value of $979,440.00. Following the transaction, the director directly owned 5,130 shares in the company, valued at approximately $418,710.60. This trade represents a 70.05% decrease in their position. The sale was disclosed in a document filed with the SEC, which can be accessed through this hyperlink. Company insiders own  4.90% of the company's stock. </p><h2>Protagonist Therapeutics Stock Performance</h2><ul><li>Are (More) Big Gains Ahead for This Small Cap Biotech Stock?</li></ul><p>NASDAQ PTGX opened at $86.05 on Monday. The firm's fifty day moving average is $83.39 and its two-hundred day moving average is $66.53. Protagonist Therapeutics, Inc. has a one year low of $33.70 and a one year high of $96.54. The firm has a market cap of $5.38 billion, a PE ratio of 138.79 and a beta of 2.19. </p><p>Protagonist Therapeutics (NASDAQ:PTGX - Get Free Report) last released its quarterly earnings results on Thursday, November 6th. The company reported ($0.62) earnings per share (EPS) for the quarter, missing analysts' consensus estimates of ($0.59) by ($0.03). The company had revenue of $4.71 million for the quarter, compared to analysts' expectations of $5.41 million. Protagonist Therapeutics had a return on equity of 6.86% and a net margin of 21.94%. Research analysts predict that  Protagonist Therapeutics, Inc. will post 2.43 earnings per share for the current year. </p><h2>Analyst Upgrades and Downgrades</h2><p>Several analysts have recently weighed in on the stock. BTIG Research  restated a &#34;buy&#34; rating and set a $82.00 price objective on shares of Protagonist Therapeutics in a research report on Tuesday, October 28th. Weiss Ratings  reiterated a &#34;sell (d+)&#34; rating on shares of Protagonist Therapeutics in a research note on Wednesday, October 8th. HC Wainwright  reissued a &#34;buy&#34; rating and issued a $80.00 price target on shares of Protagonist Therapeutics in a research report on Wednesday, October 8th. Citigroup raised their price objective on Protagonist Therapeutics from $98.00 to $115.00 and gave the stock a &#34;buy&#34; rating in a report on Monday, December 8th. Finally, JPMorgan Chase &amp; Co. boosted their target price on Protagonist Therapeutics from $68.00 to $81.00 and gave the company an &#34;overweight&#34; rating in a report on Friday, November 7th. One equities research analyst  has rated the stock with a Strong Buy rating, eleven have assigned  a Buy rating, one  has issued  a Hold rating and one  has assigned  a Sell rating to the company. Based on data from MarketBeat, Protagonist Therapeutics presently has an average rating of &#34;Moderate Buy&#34; and a consensus target price of $85.08.</p><p><b>Get Our Latest Stock Report on Protagonist Therapeutics</b></p><h2>Protagonist Therapeutics Profile</h2> (Free Report)<p>Protagonist Therapeutics, Inc <span>NASDAQ: PTGX<span></span></span> is a clinical-stage biopharmaceutical company focused on the development of novel, orally administered peptide-based therapies for immune-mediated and other serious diseases. The company leverages its proprietary Peptide 2.0 platform to design peptides that target G protein–coupled receptors and cytokine receptors, with the goal of combining the potency of biologics with the convenience of oral administration. Protagonist's approach aims to address unmet medical needs in areas where injectable therapies have been the standard of care.  </p><p>Among its lead programs is PTG-100, an oral α4β7 integrin antagonist intended to block leukocyte migration to the gut in ulcerative colitis and Crohn's disease.</p><h2>Read More</h2><ul><li>Five stocks we like better than Protagonist Therapeutics</li><li>I Shouldn't Be Sending You This</li><li>REVEALED: America just unlocked a $500 trillion asset</li><li>Wall Street Stock picker Names #1 Stock of 2026</li><li>They Laughed at $30. They Won’t Laugh at $70.</li><li>How Long Will $1M Last in Retirement?</li></ul><p><img src="https://imageproxy.pbkrs.com/https://www.marketbeat.com/scripts/SECFilingChart.ashx/query-UHJlZml4PU5BU0RBUSZTeW1ib2w9UFRHWA?x-oss-process=image/auto-orient,1/interlace,1/resize,w_1440,h_1440/quality,q_95/format,jpg" width="650" height="350" original-src="https://imageproxy.pbkrs.com/https://www.marketbeat.com/scripts/SECFilingChart.ashx/query-UHJlZml4PU5BU0RBUSZTeW1ib2w9UFRHWA"/></p><p><em>This instant news alert was generated by narrative science technology and financial data from MarketBeat in order to provide readers with the fastest reporting and unbiased coverage. Please send any questions or comments about this story to contact@marketbeat.com.</em></p><h2>Should You Invest $1,000 in Protagonist Therapeutics Right Now?</h2><p>Before you consider Protagonist Therapeutics, you'll want to hear this.</p><p>MarketBeat keeps track of Wall Street's top-rated and best performing research analysts and the stocks they recommend to their clients on a daily basis. MarketBeat has identified the five stocks that top analysts are quietly whispering to their clients to buy now before the broader market catches on... and Protagonist Therapeutics wasn't on the list.</p><p>While Protagonist Therapeutics currently has a Moderate Buy rating among analysts, top-rated analysts believe these five stocks are better buys.</p><p>View The Five Stocks Here</p>                  </div>

PTGX

<p>Assenagon Asset Management S.A. reduced its stake in Protagonist Therapeutics, Inc. by 28.4% in Q3, owning 65,756 shares worth $4.37 million. Other institutional investors also adjusted their holdings. Protagonist's stock opened at $86.05, with a market cap of $5.38 billion. Analysts have mixed ratings, with some upgrading their price targets.</p>

Assenagon Asset Management S.A. Decreases Stock Holdings in Protagonist Therapeutics, Inc. $PTGX