<div id="readability-page-1"><article>Aptevo Therapeutics Inc. (NASDAQ:APVO), a clinical-stage biotechnology company focused on developing novel immune-oncology therapeutics based on its proprietary ADAPTIR™ and ADAPTIR-FLEX™ platform technologies, today announced that it will conduct a reverse stock split of its outstanding shares of common stock, par value $0.001 per share (&#34;Common Stock&#34;), at a ratio of 1-for-18 (the &#34;Reverse Stock Split&#34;).The Reverse Stock Split is expected to become effective on December 29, at 5:01 p.m. Eastern Time (the &#34;Effective Time&#34;), with shares expected to begin trading on the Nasdaq Capital Market, on a split-adjusted basis, at market open on December 30, 2025. In connection with the Reverse Stock Split, every 18 shares of Common Stock issued and outstanding as of the Effective Time will be automatically converted into one share of Common Stock. No change will be made to the trading symbol for the Common Stock, &#34;APVO,&#34; in connection with the Reverse Stock Split.The Reverse Stock Split was approved by the Company's stockholders at the Company's Annual Meeting of Stockholders held on July 24, 2025 (the &#34;Annual Meeting&#34;) to be effected in the Board's discretion within approved parameters. Following the Annual Meeting, the final ratio was approved by the Company's Board on December 17, 2025.The Reverse Stock Split will reduce the number of shares of outstanding Common Stock from approximately 18 million shares (as of the date of this press release) to approximately 1 million shares, subject to adjustment for rounding, as discussed below and potential additional issuances through the effective date of the Reverse Stock Split.The Reverse Stock Split will affect all issued and outstanding shares of Common Stock. All outstanding options, restricted stock units, warrants, and other securities entitling their holders to purchase or otherwise receive shares of Common Stock will be adjusted as a result of the reverse split, as required by the terms of each security. The number of shares available to be awarded under the Company's equity incentive plans will also be appropriately adjusted. Following the reverse split, the par value of the Common Stock will remain unchanged at $0.001 par value per share. The Reverse Stock Split will not change the authorized number of shares of Common Stock or preferred stock. No fractional shares will be issued in connection with the Reverse Stock Split, and stockholders who would otherwise be entitled to receive a fractional share of Common Stock will be entitled to receive a cash payment (without interest).Additional information regarding the Reverse Stock Split is available in the Company's definitive proxy statement filed with the U.S. Securities and Exchange Commission (&#34;SEC&#34;) on July 3, 2025, and a Current Report on Form 8-K which the Company plans to file following the Effective Time.About Aptevo Therapeutics Aptevo Therapeutics Inc. (NASDAQ:APVO) is a clinical-stage biotechnology company focused on developing novel bispecific and trispecific immunotherapies for the treatment of cancer. The Company has two clinical candidates. Mipletamig is currently being evaluated in RAINIER, a two-part Phase 1b/2 trial for the treatment of frontline acute myeloid leukemia in combination with standard-of-care venetoclax + azacitidine. Mipletamig has received orphan drug designation (&#34;orphan status&#34;) for AML according to the Orphan Drug Act. ALG.APV-527, a bispecific conditional 4-1BB agonist, only active upon simultaneous binding to 4-1BB and 5T4, is being co-developed with Alligator Bioscience and was most recently evaluated in a Phase 1 clinical trial for the treatment of multiple solid tumor types likely to express 5T4. The Company has six preclinical candidates with different mechanisms of action designed to target a range of solid tumors. All pipeline candidates were created from two proprietary platforms, ADAPTIRand ADAPTIR-FLEX. The Aptevo mission is to improve treatment outcomes and transform the lives of cancer patients. For more information, please visit www.aptevotherapeutics.com.Forward-Looking Statements This press release includes &#34;forward-looking statements&#34;, including information about management's view of the Company's future expectations, plans and prospects, within the safe harbor provisions provided under federal securities laws, including under The Private Securities Litigation Reform Act of 1995. Words such as &#34;expect,&#34; &#34;estimate,&#34; &#34;project,&#34; &#34;budget,&#34; &#34;forecast,&#34; &#34;anticipate,&#34; &#34;intend,&#34; &#34;plan,&#34; &#34;may,&#34; &#34;will,&#34; &#34;could,&#34; &#34;should,&#34; &#34;believes,&#34; &#34;predicts,&#34; &#34;potential,&#34; &#34;continue&#34; and similar expressions are intended to identify such forward-looking statements. These forward-looking statements involve significant risks and uncertainties that could cause the actual results to differ materially from the expected results and, consequently, you should not rely on these forward-looking statements as predictions of future events. These forward-looking statements and factors that may cause such differences include, without limitation, our ability to continue as a going concern; a deterioration in Aptevo's business or prospects; further assessment of preliminary or interim data or different results from later clinical trials; adverse events and unanticipated problems and adverse developments in clinical development, including unexpected safety issues observed during a clinical trial; and changes in regulatory, social, macroeconomic and political conditions. These risks are not exhaustive, the Company faces known and unknown risks. Additional risks and factors that may affect results of the Company are set forth in the Company's filings with the SEC, including its Annual Report on Form 10-K for the fiscal year ended December 31, 2024, and its subsequent reports on Form 10-Q and current reports on Form 8-K. The foregoing sets forth many, but not all, of the factors that could cause actual results to differ from the Company's expectations in any forward-looking statement. Readers are cautioned not to place undue reliance upon any forward-looking statements, including but not limited to statements about the effectuation of the Reverse Stock Split. These reports and filings are available at www.sec.gov and are available for download, free of charge, soon after such reports are filed with or furnished to the SEC, on the &#34;Investors&#34; page of the Company's website at www.apvotherapeutics.com. Any forward-looking statement speaks only as of the date of this press release, and, except as required by law, the Company does not assume any obligation to update any forward-looking statement to reflect new information, events, or circumstances.Contact: Miriam Weber Miller Head, Investor Relations &amp; Corporate Communications Aptevo Therapeutics Email: IR@apvo.com or Millerm@apvo.com Phone: 206-859-6628SOURCE: Aptevo TherapeuticsView the original press release on ACCESS Newswire<img height="0" src="https://imageproxy.pbkrs.com/https://app.accessnewswire.com/img.ashx/query-aWQ9MTEyMTIzMw?x-oss-process=image/auto-orient,1/interlace,1/resize,w_1440,h_1440/quality,q_95/format,jpg" width="0" original-src="https://imageproxy.pbkrs.com/https://app.accessnewswire.com/img.ashx/query-aWQ9MTEyMTIzMw"/></article></div>

APVO

Aptevo Therapeutics Inc. (NASDAQ:APVO) announced a 1-for-18 reverse stock split of its common stock, effective December 29, 2025. The split will reduce the number of outstanding shares from 18 million to 1 million. The trading symbol 'APVO' will remain unchanged. The reverse split was approved by stockholders and the Board. No fractional shares will be issued; cash payments will be made instead. Further details are available in the company's SEC filings.

Aptevo Therapeutics Announces 1-for-18 Reverse Stock Split | APVO Stock News