<p>RNS 编号：9099K PureTech Health PLC2025 年 12 月 10 日</p>
<p>TR-1：主要持股通知的标准表格</p>
<ol>
<li>发行人详情</li>
</ol>
<p>ISIN</p>
<p>GB00BY2Z0H74</p>
<p>发行人名称</p>
<p>PURETECH HEALTH PLC</p>
<p>英国或非英国发行人</p>
<p>英国</p>
<ol>
<li>通知原因</li>
</ol>
<p>投票权的收购或处置</p>
<ol>
<li>受通知义务约束的个人详情</li>
</ol>
<p>姓名</p>
<p>Baillie Gifford &amp; Co</p>
<p>注册办公室所在城市（如适用）</p>
<p>爱丁堡</p>
<p>注册办公室所在国家（如适用）</p>
<p>英国</p>
<ol>
<li>股东详情</li>
</ol>
<p>如果与上述受通知义务约束的个人不同，股东的全名</p>
<p>注册办公室所在城市（如适用）</p>
<p>注册办公室所在国家（如适用）</p>
<ol>
<li>超过或达到阈值的日期</li>
</ol>
<p>2025 年 12 月 8 日</p>
<ol>
<li>发行人通知的日期</li>
</ol>
<p>2025 年 12 月 9 日</p>
<ol>
<li>受通知义务约束的个人的总持仓</li>
</ol>
<table>
<thead>
<tr>
<th></th>
<th></th>
<th></th>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td></td>
<td>附加于股份的投票权百分比（8.A 总计）</td>
<td>通过金融工具的投票权百分比（8.B 1 + 8.B 2 总计）</td>
<td>两者总和的百分比（8.A + 8.B）</td>
<td>发行人持有的投票权总数</td>
</tr>
<tr>
<td>超过或达到阈值时的结果情况</td>
<td>4.810000</td>
<td>0.000000</td>
<td>4.810000</td>
<td>11625873</td>
</tr>
<tr>
<td>之前通知的持仓情况（如适用）</td>
<td>5.280000</td>
<td>0.000000</td>
<td>5.280000</td>
<td>12,529,837</td>
</tr>
</tbody>
</table>
<ol>
<li>超过或达到阈值时的结果情况的通知详情</li>
</ol>
<p>8A. 附加于股份的投票权</p>
<table>
<thead>
<tr>
<th></th>
<th></th>
<th></th>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>股份类别/类型 ISIN 代码（如可能）</td>
<td>直接投票权数量（DTR5.1）</td>
<td>间接投票权数量（DTR5.2.1）</td>
<td>直接投票权的百分比（DTR5.1）</td>
<td>间接投票权的百分比（DTR5.2.1）</td>
</tr>
<tr>
<td>GB00BY2Z0H74</td>
<td></td>
<td>11625873</td>
<td></td>
<td>4.810000</td>
</tr>
<tr>
<td>小计 8.A</td>
<td>11625873</td>
<td>4.810000%</td>
<td></td>
<td></td>
</tr>
</tbody>
</table>
<p>8B1. 根据 (DTR5.3.1R.(1) (a)) 的金融工具</p>
<table>
<thead>
<tr>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>金融工具类型</td>
<td>小计 8.B1</td>
</tr>
<tr>
<td>到期日</td>
<td></td>
</tr>
<tr>
<td>行使/转换期限</td>
<td></td>
</tr>
<tr>
<td>如果行使/转换该工具可获得的投票权数量</td>
<td></td>
</tr>
<tr>
<td>投票权的百分比</td>
<td></td>
</tr>
</tbody>
</table>
<p>8B2. 根据 (DTR5.3.1R.(1) (b)) 具有类似经济效果的金融工具</p>
<table>
<thead>
<tr>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>金融工具类型</td>
<td>小计 8.B2</td>
</tr>
<tr>
<td>到期日</td>
<td></td>
</tr>
<tr>
<td>行使/转换期限</td>
<td></td>
</tr>
<tr>
<td>实物或现金结算</td>
<td></td>
</tr>
<tr>
<td>投票权数量</td>
<td></td>
</tr>
<tr>
<td>投票权的百分比</td>
<td></td>
</tr>
</tbody>
</table>
<ol>
<li>关于受通知义务约束的个人的信息</li>
</ol>
<ol>
<li>通过最终控制自然人或法人有效持有投票权和/或金融工具的受控企业的完整链条（如有必要，请添加额外行）</li>
</ol>
<table>
<thead>
<tr>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>最终控制人</td>
<td>Baillie Gifford &amp; Co</td>
</tr>
<tr>
<td>受控企业名称</td>
<td>Baillie Gifford &amp; Co</td>
</tr>
<tr>
<td>如果等于或高于可通知阈值的投票权百分比</td>
<td></td>
</tr>
<tr>
<td>如果等于或高于可通知阈值的通过金融工具的投票权百分比</td>
<td></td>
</tr>
<tr>
<td>如果等于或高于可通知阈值的两者总和</td>
<td></td>
</tr>
</tbody>
</table>
<ol>
<li>在代理投票的情况下</li>
</ol>
<p>代理持有人的姓名</p>
<p>持有的投票权数量和百分比</p>
<p>持有投票权的截止日期</p>
<ol>
<li>附加信息</li>
</ol>
<ol>
<li>完成日期</li>
</ol>
<p>2025 年 12 月 9 日</p>
<ol>
<li>完成地点</li>
</ol>
<p>爱丁堡</p>
<p>此信息由 RNS 提供，伦敦证券交易所的新闻服务。RNS 获得金融行为监管局的批准，作为英国的主要信息提供者。有关使用和分发此信息的条款和条件可能适用。如需更多信息，请联系 rns@lseg.com 或访问 www.rns.com。</p>
<p>RNS 可能会使用您的 IP 地址以确认遵守条款和条件，分析您与本通信中包含的信息的互动，并在我们的商业服务中以匿名方式与他人共享此分析。如需了解有关 RNS 和伦敦证券交易所如何使用您提供的个人数据的更多信息，请参见我们的隐私政策。结束 HOLTLBLTMTBMBBA</p>

PRTC

<p>PureTech Health PLC 宣布主要持股发生变化，Baillie Gifford & Co 的投票权从 5.28% 减少至 4.81%。该通知是由于投票权的收购或处置而触发的，发生在 2025 年 12 月 8 日，并于 2025 年 12 月 9 日报告。Baillie Gifford & Co 总部位于英国爱丁堡</p>

<p>RNS Number : 9099K PureTech Health PLC 10 December 2025</p>
<div class="lb-trans"><p>RNS 编号：9099K PureTech Health PLC2025 年 12 月 10 日</p>
</div><p>TR-1: Standard form for notification of major holdings</p>
<div class="lb-trans"><p>TR-1：主要持股通知的标准表格</p>
</div><p>1. Issuer Details</p>
<div class="lb-trans"><ol>
<li>发行人详情</li>
</ol>
</div><p>ISIN</p>
<div class="lb-trans"><p>ISIN</p>
</div><p>GB00BY2Z0H74</p>
<div class="lb-trans"><p>GB00BY2Z0H74</p>
</div><p>Issuer Name</p>
<div class="lb-trans"><p>发行人名称</p>
</div><p>PURETECH HEALTH PLC</p>
<div class="lb-trans"><p>PURETECH HEALTH PLC</p>
</div><p>UK or Non-UK Issuer</p>
<div class="lb-trans"><p>英国或非英国发行人</p>
</div><p>UK</p>
<div class="lb-trans"><p>英国</p>
</div><p>2. Reason for Notification</p>
<div class="lb-trans"><ol>
<li>通知原因</li>
</ol>
</div><p>An acquisition or disposal of voting rights</p>
<div class="lb-trans"><p>投票权的收购或处置</p>
</div><p>3. Details of person subject to the notification obligation</p>
<div class="lb-trans"><ol>
<li>受通知义务约束的个人详情</li>
</ol>
</div><p>Name</p>
<div class="lb-trans"><p>姓名</p>
</div><p>Baillie Gifford &amp; Co</p>
<div class="lb-trans"><p>Baillie Gifford &amp; Co</p>
</div><p>City of registered office (if applicable)</p>
<div class="lb-trans"><p>注册办公室所在城市（如适用）</p>
</div><p>Edinburgh</p>
<div class="lb-trans"><p>爱丁堡</p>
</div><p>Country of registered office (if applicable)</p>
<div class="lb-trans"><p>注册办公室所在国家（如适用）</p>
</div><p>United Kingdom</p>
<div class="lb-trans"><p>英国</p>
</div><p>4. Details of the shareholder</p>
<div class="lb-trans"><ol>
<li>股东详情</li>
</ol>
</div><p>Full name of shareholder(s) if different from the person(s) subject to the notification obligation, above</p>
<div class="lb-trans"><p>如果与上述受通知义务约束的个人不同，股东的全名</p>
</div><p>City of registered office (if applicable)</p>
<div class="lb-trans"><p>注册办公室所在城市（如适用）</p>
</div><p>Country of registered office (if applicable)</p>
<div class="lb-trans"><p>注册办公室所在国家（如适用）</p>
</div><p>5. Date on which the threshold was crossed or reached</p>
<div class="lb-trans"><ol>
<li>超过或达到阈值的日期</li>
</ol>
</div><p>08-Dec-2025</p>
<div class="lb-trans"><p>2025 年 12 月 8 日</p>
</div><p>6. Date on which Issuer notified</p>
<div class="lb-trans"><ol>
<li>发行人通知的日期</li>
</ol>
</div><p>09-Dec-2025</p>
<div class="lb-trans"><p>2025 年 12 月 9 日</p>
</div><p>7. Total positions of person(s) subject to the notification obligation</p>
<div class="lb-trans"><ol>
<li>受通知义务约束的个人的总持仓</li>
</ol>
</div><table>
<thead>
<tr>
<th></th>
<th></th>
<th></th>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td></td>
<td>% of voting rights attached to shares (total of 8.A)</td>
<td>% of voting rights through financial instruments (total of 8.B 1 + 8.B 2)</td>
<td>Total of both in % (8.A + 8.B)</td>
<td>Total number of voting rights held in issuer</td>
</tr>
<tr>
<td>Resulting situation on the date on which threshold was crossed or reached</td>
<td>4.810000</td>
<td>0.000000</td>
<td>4.810000</td>
<td>11625873</td>
</tr>
<tr>
<td>Position of previous notification (if applicable)</td>
<td>5.280000</td>
<td>0.000000</td>
<td>5.280000</td>
<td>12,529,837</td>
</tr>
</tbody>
</table>
<div class="lb-trans"><table>
<thead>
<tr>
<th></th>
<th></th>
<th></th>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td></td>
<td>附加于股份的投票权百分比（8.A 总计）</td>
<td>通过金融工具的投票权百分比（8.B 1 + 8.B 2 总计）</td>
<td>两者总和的百分比（8.A + 8.B）</td>
<td>发行人持有的投票权总数</td>
</tr>
<tr>
<td>超过或达到阈值时的结果情况</td>
<td>4.810000</td>
<td>0.000000</td>
<td>4.810000</td>
<td>11625873</td>
</tr>
<tr>
<td>之前通知的持仓情况（如适用）</td>
<td>5.280000</td>
<td>0.000000</td>
<td>5.280000</td>
<td>12,529,837</td>
</tr>
</tbody>
</table>
</div><p>8. Notified details of the resulting situation on the date on which the threshold was crossed or reached</p>
<div class="lb-trans"><ol>
<li>超过或达到阈值时的结果情况的通知详情</li>
</ol>
</div><p>8A. Voting rights attached to shares</p>
<div class="lb-trans"><p>8A. 附加于股份的投票权</p>
</div><table>
<thead>
<tr>
<th></th>
<th></th>
<th></th>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>Class/Type of shares ISIN code(if possible)</td>
<td>Number of direct voting rights (DTR5.1)</td>
<td>Number of indirect voting rights (DTR5.2.1)</td>
<td>% of direct voting rights (DTR5.1)</td>
<td>% of indirect voting rights (DTR5.2.1)</td>
</tr>
<tr>
<td>GB00BY2Z0H74</td>
<td></td>
<td>11625873</td>
<td></td>
<td>4.810000</td>
</tr>
<tr>
<td>Sub Total 8.A</td>
<td>11625873</td>
<td>4.810000%</td>
<td></td>
<td></td>
</tr>
</tbody>
</table>
<div class="lb-trans"><table>
<thead>
<tr>
<th></th>
<th></th>
<th></th>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>股份类别/类型 ISIN 代码（如可能）</td>
<td>直接投票权数量（DTR5.1）</td>
<td>间接投票权数量（DTR5.2.1）</td>
<td>直接投票权的百分比（DTR5.1）</td>
<td>间接投票权的百分比（DTR5.2.1）</td>
</tr>
<tr>
<td>GB00BY2Z0H74</td>
<td></td>
<td>11625873</td>
<td></td>
<td>4.810000</td>
</tr>
<tr>
<td>小计 8.A</td>
<td>11625873</td>
<td>4.810000%</td>
<td></td>
<td></td>
</tr>
</tbody>
</table>
</div><p>8B1. Financial Instruments according to (DTR5.3.1R.(1) (a))</p>
<div class="lb-trans"><p>8B1. 根据 (DTR5.3.1R.(1) (a)) 的金融工具</p>
</div><table>
<thead>
<tr>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>Type of financial instrument</td>
<td>Sub Total 8.B1</td>
</tr>
<tr>
<td>Expiration date</td>
<td></td>
</tr>
<tr>
<td>Exercise/conversion period</td>
<td></td>
</tr>
<tr>
<td>Number of voting rights that may be acquired if the instrument is exercised/converted</td>
<td></td>
</tr>
<tr>
<td>% of voting rights</td>
<td></td>
</tr>
</tbody>
</table>
<div class="lb-trans"><table>
<thead>
<tr>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>金融工具类型</td>
<td>小计 8.B1</td>
</tr>
<tr>
<td>到期日</td>
<td></td>
</tr>
<tr>
<td>行使/转换期限</td>
<td></td>
</tr>
<tr>
<td>如果行使/转换该工具可获得的投票权数量</td>
<td></td>
</tr>
<tr>
<td>投票权的百分比</td>
<td></td>
</tr>
</tbody>
</table>
</div><p>8B2. Financial Instruments with similar economic effect according to (DTR5.3.1R.(1) (b))</p>
<div class="lb-trans"><p>8B2. 根据 (DTR5.3.1R.(1) (b)) 具有类似经济效果的金融工具</p>
</div><table>
<thead>
<tr>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>Type of financial instrument</td>
<td>Sub Total 8.B2</td>
</tr>
<tr>
<td>Expiration date</td>
<td></td>
</tr>
<tr>
<td>Exercise/conversion period</td>
<td></td>
</tr>
<tr>
<td>Physical or cash settlement</td>
<td></td>
</tr>
<tr>
<td>Number of voting rights</td>
<td></td>
</tr>
<tr>
<td>% of voting rights</td>
<td></td>
</tr>
</tbody>
</table>
<div class="lb-trans"><table>
<thead>
<tr>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>金融工具类型</td>
<td>小计 8.B2</td>
</tr>
<tr>
<td>到期日</td>
<td></td>
</tr>
<tr>
<td>行使/转换期限</td>
<td></td>
</tr>
<tr>
<td>实物或现金结算</td>
<td></td>
</tr>
<tr>
<td>投票权数量</td>
<td></td>
</tr>
<tr>
<td>投票权的百分比</td>
<td></td>
</tr>
</tbody>
</table>
</div><p>9. Information in relation to the person subject to the notification obligation</p>
<div class="lb-trans"><ol>
<li>关于受通知义务约束的个人的信息</li>
</ol>
</div><p>2. Full chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held starting with the ultimate controlling natural person or legal entities (please add additional rows as necessary)</p>
<div class="lb-trans"><ol>
<li>通过最终控制自然人或法人有效持有投票权和/或金融工具的受控企业的完整链条（如有必要，请添加额外行）</li>
</ol>
</div><table>
<thead>
<tr>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>Ultimate controlling person</td>
<td>Baillie Gifford &amp; Co</td>
</tr>
<tr>
<td>Name of controlled undertaking</td>
<td>Baillie Gifford &amp; Co</td>
</tr>
<tr>
<td>% of voting rights if it equals or is higher than the notifiable threshold</td>
<td></td>
</tr>
<tr>
<td>% of voting rights through financial instruments if it equals or is higher than the notifiable threshold</td>
<td></td>
</tr>
<tr>
<td>Total of both if it equals or is higher than the notifiable threshold</td>
<td></td>
</tr>
</tbody>
</table>
<div class="lb-trans"><table>
<thead>
<tr>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>最终控制人</td>
<td>Baillie Gifford &amp; Co</td>
</tr>
<tr>
<td>受控企业名称</td>
<td>Baillie Gifford &amp; Co</td>
</tr>
<tr>
<td>如果等于或高于可通知阈值的投票权百分比</td>
<td></td>
</tr>
<tr>
<td>如果等于或高于可通知阈值的通过金融工具的投票权百分比</td>
<td></td>
</tr>
<tr>
<td>如果等于或高于可通知阈值的两者总和</td>
<td></td>
</tr>
</tbody>
</table>
</div><p>10. In case of proxy voting</p>
<div class="lb-trans"><ol>
<li>在代理投票的情况下</li>
</ol>
</div><p>Name of the proxy holder</p>
<div class="lb-trans"><p>代理持有人的姓名</p>
</div><p>The number and % of voting rights held</p>
<div class="lb-trans"><p>持有的投票权数量和百分比</p>
</div><p>The date until which the voting rights will be held</p>
<div class="lb-trans"><p>持有投票权的截止日期</p>
</div><p>11. Additional Information</p>
<div class="lb-trans"><ol>
<li>附加信息</li>
</ol>
</div><p>12. Date of Completion</p>
<div class="lb-trans"><ol>
<li>完成日期</li>
</ol>
</div><p>09-Dec-2025</p>
<div class="lb-trans"><p>2025 年 12 月 9 日</p>
</div><p>13. Place Of Completion</p>
<div class="lb-trans"><ol>
<li>完成地点</li>
</ol>
</div><p>Edinburgh</p>
<div class="lb-trans"><p>爱丁堡</p>
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