<p>作者：Jaimy Lee</p>
<p>投资者史蒂夫·艾斯曼正在接受乳腺癌治疗。</p>
<p>史蒂夫·艾斯曼，这位因在全球金融危机前对美国房地产市场做空而闻名的交易员，表示他正在接受乳腺癌治疗。</p>
<p>史蒂夫·艾斯曼是一位对冲基金交易员，以在 2007-09 年经济衰退前成功做空房地产市场而闻名于华尔街。他在金融危机前的经历在畅销书《大空头》中详细描述，该书被改编成了一部热门电影。</p>
<p>周四，艾斯曼在 CNBC 上讲述了他健康状况的感人故事，称他患有乳腺癌并正在接受治疗。根据美国癌症协会的数据，男性乳腺癌的诊断不到 1%，而且通常发生在 60 至 70 岁的男性身上。</p>
<p>在采访中，艾斯曼，现年 60 出头，表示他的一位肿瘤科医生朋友在他们 6 月打完壁球后，在健身房的更衣室里注意到他左侧乳房的皮肤刺激。</p>
<p>“他看着我，说，‘那是什么？’ 我回答，‘什么？’” 艾斯曼说。“他真的走过来，开始在更衣室给我做乳房检查。”</p>
<p>“我立刻就知道了，” 他的朋友罗伯特·盖尔芬德说，他在纽约市经营一个输液中心网络。</p>
<p>他催促艾斯曼立即进行乳腺 X 光检查。随后，艾斯曼被诊断出，进行了双侧乳腺切除手术，并接受两种化疗：紫杉醇和 AC（阿霉素和环磷酰胺）。他将在本月完成化疗，并将在 1 月开始放疗。</p>
<p>“女性经常面临这种情况，” 艾斯曼说。“我提到这个的原因是，虽然男性罕见，但并非闻所未闻。”</p>
<p>医生和研究人员对男性乳腺癌的了解不如女性，但这一情况正在慢慢改变。医生们意识到某些因素可能会增加男性患病的风险，包括年龄较大或从父母那里遗传 BRCA 基因突变。</p>
<p>拥有突变的 BRCA 基因会增加多种癌症的风险，包括乳腺癌、卵巢癌、前列腺癌和胰腺癌。阿什肯纳兹犹太人和冰岛裔人群更可能拥有突变的 BRCA 基因，这也是一些女性选择进行预防性乳腺切除或子宫切除的原因。这也是男性患乳腺癌的最大已知风险因素，波士顿 Dana-Farber 癌症研究所的乳腺肿瘤学家哈尔·伯斯坦告诉 MarketWatch。伯斯坦并未参与艾斯曼的治疗。</p>
<p>BRCA 基因有两种类型。根据 2022 年发表在《临床肿瘤学杂志》上的一项研究，BRCA1 突变会使男性在 70 岁时患乳腺癌的风险增加至 1.2%，而 BRCA2 突变则可能使风险增加至 7.1%。</p>
<p>根据 2018 年发表在《新英格兰医学杂志》上的一项研究，男性乳腺癌的生存率通常低于女性。这可能与诊断年龄以及男性并不定期接受乳腺癌筛查有关。当男性发现自己有肿块时，癌症往往已经处于更晚期。</p>
<p>“男性需要提高警惕，” 艾斯曼说。</p>
<p>在过去十年左右，针对基因突变影响癌症风险的人群，市场上出现了一波更好的癌症检测和治疗方法。阿斯利康（AstraZeneca）的 Lynparza 是 2014 年首次获批专门治疗 BRCA 突变卵巢癌的药物。现在它也被批准用于治疗相关的乳腺癌，有时也用于男性。人们对男性乳腺癌的认识也在不断提高，越来越多的研究人员现在开始招募男性参与乳腺癌临床试验。</p>
<p>“迄今为止，男性乳腺癌治疗几乎没有随机试验报告，” 伯斯坦说。“我们借鉴了治疗女性乳腺癌的所有经验。”</p>
<p>当名人或其他知名人士如艾斯曼披露医疗诊断时，有时会导致所谓的 “安吉丽娜效应”，指的是在演员安吉丽娜·朱莉在 2013 年分享她因携带 BRCA1 基因突变而进行预防性双侧乳腺切除后，BRCA 检测率的增加。一个知名人士是马修·诺尔斯，碧昂丝的父亲，他曾表示自己被诊断出乳腺癌并携带 BRCA2 突变。</p>
<p>艾斯曼在 CNBC 采访中没有说明他是否携带 BRCA 突变，他呼吁男性在注意到任何变化时寻求医疗帮助。</p>
<p>“只需检查一下，” 他说。“在乳腺 X 光检查后，医生对我说，‘你的朋友救了你的命。’”</p>
<p>-Jaimy Lee</p>
<p>本文由 MarketWatch 创作，MarketWatch 由道琼斯公司运营。MarketWatch 与道琼斯新闻通讯和《华尔街日报》独立出版。</p>
<p>（完）道琼斯新闻通讯</p>
<p>12-14-25 0939ET</p>

<p>史蒂夫·艾斯曼因在《大空头》中的角色而闻名，目前正在接受乳腺癌治疗，这在男性中是一种罕见的疾病。在朋友的观察后被诊断出，艾斯曼进行了双侧乳腺切除手术，并正在接受化疗。男性乳腺癌的了解程度较低，但人们的意识正在提高。艾斯曼呼吁男性对任何变化寻求医疗建议，强调早期发现的重要性</p>

<p>By Jaimy Lee</p>
<div class="lb-trans"><p>作者：Jaimy Lee</p>
</div><p>The investor Steve Eisman is undergoing treatment for breast cancer.</p>
<div class="lb-trans"><p>投资者史蒂夫·艾斯曼正在接受乳腺癌治疗。</p>
</div><p>Steve Eisman, the trader known for betting against the U.S. housing market before the global financial crisis, said he is undergoing treatment for breast cancer.</p>
<div class="lb-trans"><p>史蒂夫·艾斯曼，这位因在全球金融危机前对美国房地产市场做空而闻名的交易员，表示他正在接受乳腺癌治疗。</p>
</div><p>Steve Eisman is a hedge-fund trader best known on Wall Street for successfully betting against the housing market before the recession of 2007-09. His experiences in the lead-up to the financial crisis were detailed in &#34;The Big Short,&#34; a bestselling book that was made into a hit movie.</p>
<div class="lb-trans"><p>史蒂夫·艾斯曼是一位对冲基金交易员，以在 2007-09 年经济衰退前成功做空房地产市场而闻名于华尔街。他在金融危机前的经历在畅销书《大空头》中详细描述，该书被改编成了一部热门电影。</p>
</div><p>On Thursday, Eisman went on CNBC and told a moving story about his health, saying he has breast cancer and is undergoing treatment for the disease. Fewer than 1% of breast cancer diagnoses occur in men, and when they do, it's usually in men who are between the ages of 60 and 70, according to the American Cancer Society.</p>
<div class="lb-trans"><p>周四，艾斯曼在 CNBC 上讲述了他健康状况的感人故事，称他患有乳腺癌并正在接受治疗。根据美国癌症协会的数据，男性乳腺癌的诊断不到 1%，而且通常发生在 60 至 70 岁的男性身上。</p>
</div><p>In the interview, Eisman, who is in his early 60s, said that a friend who is an oncologist noticed a skin irritation on his left breast while they were in the gym locker room after playing squash in June.</p>
<div class="lb-trans"><p>在采访中，艾斯曼，现年 60 出头，表示他的一位肿瘤科医生朋友在他们 6 月打完壁球后，在健身房的更衣室里注意到他左侧乳房的皮肤刺激。</p>
</div><p>&#34;He looks at me, and he said, 'What's that? And I go, 'What's what?'&#34; Eisman said. &#34;And he literally walks over to me and starts giving me a breast exam in the locker room.&#34;</p>
<div class="lb-trans"><p>“他看着我，说，‘那是什么？’ 我回答，‘什么？’” 艾斯曼说。“他真的走过来，开始在更衣室给我做乳房检查。”</p>
</div><p>&#34;I knew immediately,&#34; said his friend, Robert Gelfand, who runs a network of infusion centers in New York City.</p>
<div class="lb-trans"><p>“我立刻就知道了，” 他的朋友罗伯特·盖尔芬德说，他在纽约市经营一个输液中心网络。</p>
</div><p>He urged Eisman to get a mammogram right away. From there, Eisman was diagnosed, underwent a double mastectomy and is being treated with two types of chemotherapy: Taxol and AC, or Adriamycin and cyclophosphamide. He will finish chemo this month and start radiation therapy in January.</p>
<div class="lb-trans"><p>他催促艾斯曼立即进行乳腺 X 光检查。随后，艾斯曼被诊断出，进行了双侧乳腺切除手术，并接受两种化疗：紫杉醇和 AC（阿霉素和环磷酰胺）。他将在本月完成化疗，并将在 1 月开始放疗。</p>
</div><p>&#34;Women face this all the time,&#34; Eisman said. &#34;The reason why I'm mentioning this is that it's rare for men, but it's not unheard of.&#34;</p>
<div class="lb-trans"><p>“女性经常面临这种情况，” 艾斯曼说。“我提到这个的原因是，虽然男性罕见，但并非闻所未闻。”</p>
</div><p>Doctors and researchers don't know as much about breast cancer in men as they do in women, but that's slowly starting to change. Physicians are aware that certain factors can elevate a man's risk of getting the disease, including being older or inheriting a BRCA gene mutation from a parent.</p>
<div class="lb-trans"><p>医生和研究人员对男性乳腺癌的了解不如女性，但这一情况正在慢慢改变。医生们意识到某些因素可能会增加男性患病的风险，包括年龄较大或从父母那里遗传 BRCA 基因突变。</p>
</div><p>Having a mutated BRCA gene increases the risk of several cancers, including breast, ovarian, prostate and pancreatic. People of Ashkenazi Jewish and Icelandic descent are more likely to have a mutated BRCA gene, and it's one reason some women undergo preventive mastectomies or hysterectomies. It's also the largest known risk factor for men who get breast cancer, Hal Burstein, a breast oncologist at the Dana-Farber Cancer Institute in Boston, told MarketWatch. Burstein is not involved in Eisman's care.</p>
<div class="lb-trans"><p>拥有突变的 BRCA 基因会增加多种癌症的风险，包括乳腺癌、卵巢癌、前列腺癌和胰腺癌。阿什肯纳兹犹太人和冰岛裔人群更可能拥有突变的 BRCA 基因，这也是一些女性选择进行预防性乳腺切除或子宫切除的原因。这也是男性患乳腺癌的最大已知风险因素，波士顿 Dana-Farber 癌症研究所的乳腺肿瘤学家哈尔·伯斯坦告诉 MarketWatch。伯斯坦并未参与艾斯曼的治疗。</p>
</div><p>There are two types of BRCA genes. A BRCA1 mutation raises the risk of breast cancer in men by up to 1.2% by age 70, while a BRCA2 mutation can increase the risk by up to 7.1%, according to a study published in 2022 in the Journal of Clinical Oncology.</p>
<div class="lb-trans"><p>BRCA 基因有两种类型。根据 2022 年发表在《临床肿瘤学杂志》上的一项研究，BRCA1 突变会使男性在 70 岁时患乳腺癌的风险增加至 1.2%，而 BRCA2 突变则可能使风险增加至 7.1%。</p>
</div><p>Survival rates for men with breast cancer tend to be lower than for women, according to a 2018 study published in the New England Journal of Medicine. This is likely due to the age of diagnosis and the fact that men aren't regularly screened for breast cancer. By the time a man has a lump that he can feel, the cancer is often at a more advanced stage.</p>
<div class="lb-trans"><p>根据 2018 年发表在《新英格兰医学杂志》上的一项研究，男性乳腺癌的生存率通常低于女性。这可能与诊断年龄以及男性并不定期接受乳腺癌筛查有关。当男性发现自己有肿块时，癌症往往已经处于更晚期。</p>
</div><p>&#34;There's a need for men to be aware,&#34; Eisman said.</p>
<div class="lb-trans"><p>“男性需要提高警惕，” 艾斯曼说。</p>
</div><p>Over the last decade or so, a wave of better cancer tests and treatments have come to market for people with gene mutations that affect cancer risk. AstraZeneca's (AZN) Lynparza was the first drug to specifically treat BRCA-mutated ovarian cancer when it was approved in 2014. It's now approved to treat related breast cancers and is sometimes used to treat men. There's also growing awareness about breast cancer in men, and more researchers are now enrolling men in breast cancer trials.</p>
<div class="lb-trans"><p>在过去十年左右，针对基因突变影响癌症风险的人群，市场上出现了一波更好的癌症检测和治疗方法。阿斯利康（AstraZeneca）的 Lynparza 是 2014 年首次获批专门治疗 BRCA 突变卵巢癌的药物。现在它也被批准用于治疗相关的乳腺癌，有时也用于男性。人们对男性乳腺癌的认识也在不断提高，越来越多的研究人员现在开始招募男性参与乳腺癌临床试验。</p>
</div><p>&#34;There have been essentially no randomized trials in the treatment of male breast cancer that have reported to date,&#34; Burstein said. &#34;We take all the lessons from treating women with breast cancer.&#34;</p>
<div class="lb-trans"><p>“迄今为止，男性乳腺癌治疗几乎没有随机试验报告，” 伯斯坦说。“我们借鉴了治疗女性乳腺癌的所有经验。”</p>
</div><p>When celebrities or other well-known figures like Eisman disclose medical diagnoses, it sometimes results in what's known as the &#34;Angelina effect,&#34; which refers to the increase in BRCA testing rates after actor Angelina Jolie shared in 2013 that she had a preventive double mastectomy upon learning she carried a BRCA1 gene mutation. One well-known person who has said he was diagnosed with breast cancer and has the BRCA2 mutation is Matthew Knowles, Beyoncé's father.</p>
<div class="lb-trans"><p>当名人或其他知名人士如艾斯曼披露医疗诊断时，有时会导致所谓的 “安吉丽娜效应”，指的是在演员安吉丽娜·朱莉在 2013 年分享她因携带 BRCA1 基因突变而进行预防性双侧乳腺切除后，BRCA 检测率的增加。一个知名人士是马修·诺尔斯，碧昂丝的父亲，他曾表示自己被诊断出乳腺癌并携带 BRCA2 突变。</p>
</div><p>Eisman, who didn't say whether he has the BRCA mutation during the CNBC interview, urged men to seek medical care if they notice any changes.</p>
<div class="lb-trans"><p>艾斯曼在 CNBC 采访中没有说明他是否携带 BRCA 突变，他呼吁男性在注意到任何变化时寻求医疗帮助。</p>
</div><p>&#34;Just check it out,&#34; he said. &#34;After the mammogram, the doctor said to me, 'Your friend saved your life.'&#34;</p>
<div class="lb-trans"><p>“只需检查一下，” 他说。“在乳腺 X 光检查后，医生对我说，‘你的朋友救了你的命。’”</p>
</div><p>-Jaimy Lee</p>
<div class="lb-trans"><p>-Jaimy Lee</p>
</div><p>This content was created by MarketWatch, which is operated by Dow Jones &amp; Co. MarketWatch is published independently from Dow Jones Newswires and The Wall Street Journal.</p>
<div class="lb-trans"><p>本文由 MarketWatch 创作，MarketWatch 由道琼斯公司运营。MarketWatch 与道琼斯新闻通讯和《华尔街日报》独立出版。</p>
</div><p>(END) Dow Jones Newswires</p>
<div class="lb-trans"><p>（完）道琼斯新闻通讯</p>
</div><p>12-14-25 0939ET</p>
<div class="lb-trans"><p>12-14-25 0939ET</p>
</div>

一场壁球比赛拯救了这位著名交易员的生命。男性乳腺癌的普遍程度如何？