<p>当 NBA 老将杰森·柯林斯在 5 月与他的长期伴侣布伦森·格林结婚时，六个月后因接受四期脑癌的实验性治疗而不得不将蜜月转移到新加坡，这并不在他的计划之内。\n 这位身高 2.13 米（7 英尺）的前中锋，47 岁，与电影制片人格林上个月在这个城市国家度过了感恩节，远离他们的大家庭，因为柯林斯正在接受他在与最具侵袭性脑癌作斗争时的第一剂 EDV（EnGeneIC Dream Vector）治疗。\n 上周四，柯林斯，第一位在美国主要职业体育联盟中公开出柜的男性，宣布他在 8 月 30 日被诊断为四期多形性胶质母细胞瘤（GBM），并正在新加坡的一家诊所接受创新治疗，他在 “48 小时内” 获得了出于同情理由的批准。\n 医生告诉柯林斯，如果他对癌症不采取任何措施，他在 NBA 打了 13 个赛季，将在六周到三个月内死亡。\n 柯林斯在接受《亚洲这一周》采访时谈到他在享受新婚生活时对诊断的感受，微笑着说：“这就是生活。”\n“生活是如此复杂，消耗负能量的精力，为什么呢？让我们尝试帮助，保持积极，把人们聚在一起，” 他在 EDV 治疗通过静脉注入到他血液中时，笑着补充道。\n 柯林斯目前正在新加坡的库里肿瘤学中心进行为期八周的实验性癌症治疗，由生物制药公司 EnGeneIC 提供，该公司使用抗体靶向的细菌衍生纳米细胞，这些细胞具有坚硬的细胞壁，可以通过肿瘤周围渗漏的血管进入肿瘤。\n 每个纳米细胞都充满了可以杀死癌细胞的高效毒性物质。当纳米细胞锁定癌细胞并被其吞噬时，癌细胞内部的毒性物质会迅速释放并杀死它——就像特洛伊木马一样。\n“感觉就像你打了一针非常强的流感疫苗，我能感觉到我的免疫系统在识别体内注入了某种东西。所以你会感到非常潮红，像发烧一样，感到疲惫，血压稍微升高，但除此之外，感觉并不糟糕，” 柯林斯说，而他的丈夫格林则指出，副作用远没有传统化疗那么毒性。\n 这对夫妇是通过柯林斯的一位高中朋友了解到 EDV 的。在格林联系了 EnGeneIC 的创始人后，新加坡很快被确定为获得治疗的最快途径。\nEnGeneIC 的联合创始人詹妮弗·麦克迪亚米德在电话采访中告诉《亚洲这一周》：“他与许多不同潜在疗法的人交谈过，最终找到了我们。他自己的医生并不热衷于进行实验性治疗，直到他经历了整个第一线和第二线治疗，但到那时，面对这种疾病，人们可能会死亡。他们可能完全没有反应。”\n 柯林斯同意说：“美国的医疗系统没有这里的反应快。”\n 当被问及是否很难决定在有限的时间内离开家时，他说：“这很困难，但仔细想想，这毫无疑问，因为你不想只是呆在家里。我爱我的家人，但我想尝试延长时间……我知道衰退的情况，以及它发生得有多快，所以我不想那样，必须在两者之间做点什么。”\n 目前，除了 EDV 治疗外，柯林斯还在接受一系列治疗，他和格林通过与其他护理人员和医疗专家交谈进行研究，同时利用人工智能筛选公开可用的数据。\n 他们前往马来西亚的吉隆坡获取一种电容癌症治疗设备，该设备使用低频、低强度的静电场来靶向和摧毁癌细胞。他还在服用抗抑郁药 Brintellix 和靶向癌症治疗药物 Avastin，这大大改善了柯林斯在 9 月的状况。\n 自 11 月底抵达新加坡以来，柯林斯表示，他与通过 NBA 网络的共同朋友建立了联系，他们对他和他的家人非常慷慨，包括为他们举办感恩节晚餐，并提供住宿以换取照看狗。\n 除了更频繁地感到疲惫外，柯林斯的身体状况良好，能够探索这个城市国家，尝试当地美食，如辣椒螃蟹，甚至在周日围绕乌节路和新加坡植物园走了两个小时，并在印尼的民丹岛度过了几天，为他和格林庆祝生日。\n“这有点好笑，因为很多人，如果他们只是看我的 Instagram，会认为我们在进行美食之旅，” 他说。\n 柯林斯目前的状态与他在 8 月中旬的状况截然不同，当时他在短期记忆方面挣扎，“就像《海底总动员》中的多莉”，他说，而在 9 月时他形容自己 “基本上是个植物人”。\n\n“我们不知道他是否会恢复，” 格林回忆起柯林斯在洛杉矶进行活检后接受的认知测试时说，当时他无法在图片卡上说出网球拍的名称，尽管他是这项运动的狂热爱好者和粉丝。“这对我们来说真的很可怕。”\n 自从上周他的诊断消息传出以来，柯林斯表示他的手机一直在响，主要是支持信息和治疗及专家的建议。他将这种经历比作他在 2013 年首次出柜时的感受。\n“自 2013 年我出柜以来，我宁愿坦诚地说，这是我正在经历的事情，这是我正在处理的事情，如果你能在这个过程中帮助某人，那就太好了。我总是尝试帮助，” 柯林斯说，他将自己能够坦诚的能力归功于他的支持系统。\n 麦克迪亚米德告诉《亚洲这一周》，像柯林斯这样的同情案例为 EnGeneIC 在临床试验中提供了重要数据，包括她希望明年 1 月或 2 月在新加坡开始的 GBM 试验。该公司在新加坡开设了子公司。\n“来自同情案例的数据……为我们提供了良好的信号，表明哪些肿瘤可能会对治疗产生反应，当然我们对 GBM 非常感兴趣，因为我们在这里和新加坡有几个患者都在良好恢复，” 她说，并赞扬新加坡的卫生科学局非常乐于帮助生命末期的人们。\n 麦克迪亚米德表示，EnGeneIC 的目标是尽快获得治疗的市场批准，这可能需要大约两年时间。\n 新加坡脑肿瘤协会主席梅丽莎·林表示，所有参与者都付出了 “超人般的努力”，将像 EDV 这样的实验性治疗引入新加坡。“他们每一条线都有决心将其引入，现在人们正在前往新加坡接受 EnGeneIC 的治疗，就像杰森一样。”\n\n 林指出，生存者的统计数据并不乐观，在她 20 年的 GBM 病例经验中，她只遇到过两例在被诊断后活过五年的患者。根据胶质母细胞瘤研究组织的数据，GBM 成年人的中位生存率为 14.6 个月。\n“我已经到了每一次心碎都导致结果的地步，这必须停止，必须对此采取行动，它已经坏到需要决心的地步，” 林说，她的协会在新加坡支持约 300 个家庭。\n 除了柯林斯，另一位接受 EDV 治疗的脑癌患者是一位 74 岁的男性，他希望保持匿名。\n 他的妻子告诉《亚洲这一周》，自从她的丈夫在医生的建议下于 9 月开始治疗以来，他的食欲恢复了，能够自己起床并在大约五分钟内剃须。\n 她注意到，在尝试治疗的头几周内，她丈夫的状况发生了显著变化，无论是在疲惫感还是独立能力方面。\n“每周，我都能看到改善。这给了我们希望的窗口，” 这位护理人员说。</p>

NNOX

<p>前 NBA 球员杰森·柯林斯被诊断为四期多形性胶质母细胞瘤，目前正在新加坡接受实验性治疗。柯林斯在五月与布伦森·格林结婚，为了治疗改变了蜜月计划。他正在接受 EDV 疗法，该疗法利用纳米细胞靶向癌症。尽管面临挑战，柯林斯依然保持积极态度，并在新加坡探索。他强调在与癌症斗争中，积极心态和主动行动的重要性</p>

<p>When National Basketball Association veteran Jason Collins married his long-term partner Brunson Green in May, having to divert his honeymoon to Singapore six months later for an experimental treatment for stage 4 brain cancer was not on his bingo card.\nThe 2.13 metre (7 feet) former centre, 47, and Green, a film producer, found themselves spending Thanksgiving in the city state last month, far from their extended family, as Collin underwent his first doses of EDV (EnGeneIC Dream Vector) in his battle against the most aggressive form of brain cancer.\nLast Thursday, Collins, the first openly gay man to play in a major US professional sports league, announced that he was diagnosed with stage 4 glioblastoma multiforme (GBM) on August 30 and was pursuing an innovative treatment in a clinic in Singapore, where he got approval under compassionate reasons “within 48 hours”.\nHad he done nothing about his cancer, doctors told Collins, who played 13 seasons in the NBA, that he would have been dead in six weeks to three months.\nSpeaking to This Week in Asia about how he felt about his diagnosis while he was enjoying retirement as a newlywed, Collins smiled and said: “It’s life.”\n“Life is so complicated that the energy that it takes to have negative energy, it’s like, why? Let’s try to help, let’s be positive and bring people together,” he added with a chuckle as the EDV treatment was being administered intravenously into his bloodstream.\n\nCollins is about midway through an eight-week stint at Curie Oncology in the city state as he undergoes the experimental cancer therapy by the biopharmaceutical company EnGeneIC, which uses antibody-targeted, bacterially derived nano cells that have a rigid cell wall that can access tumours via leaky blood vessels in and around them.\nEach nano cell is filled with highly potent toxic substances that can kill cancer cells. When a nano cell locks onto a cancer cell and is swallowed by it, the toxic substances inside the cancer cell rush out and kill it – akin to a Trojan horse.\n“It feels like when you get a very strong flu shot, and I can feel my immune system recognising that something’s been injected into the body. So you get very flushed, like a fever, you’re tired, and your blood pressure spikes a little bit, but other than that, it hasn’t been bad at all,” said Collins, while his husband Green noted that the side effects were not nearly as toxic as traditional chemotherapy.\nThe couple learned about EDVs from one of Collins’ high school friends. After Green reached out to the founders of EnGeneIC, Singapore was soon identified as the quickest way to get the treatment.\nJennifer MacDiarmid, co-founder of EnGeneIC, told This Week in Asia in a phone interview: “He talked to [people on] lots of different potential therapies, and he found us. His own physicians weren’t keen to do an experimental one until he’d gone through the whole first line and second line, but by that time, with this disease, people can die. They can become totally non-responsive.”\nThe medical system in the United States doesn’t move as quickly as it does here\nJason Collins, ex-NBA player\nCollins agreed, saying: “The medical system in the United States doesn’t move as quickly as it does here.”\nOn whether it was a tough decision to spend his limited time away from home, he said: “It was difficult, but when you think about it, it’s a no-brainer, because you don’t want to just sit at home. I love my family, but I would like to try to extend time … And I know about the decline, and how quickly it can happen, so I don’t want that, and had to do something in between.”\nCurrently, aside from the EDV treatment, Collins is on a cocktail of treatments that he and Green have researched by speaking to other carers and medical experts about, while also employing artificial intelligence to sieve through publicly available data.\nThey went to nearby Kuala Lumpur in Malaysia to get an Electro Capacitive Cancer Therapy device that uses low-frequency, low-intensity electrostatic fields to target and destroy cancer cells. He is also on antidepressant Brintellix and targeted cancer therapy Avastin, which vastly improved Collins’ condition in September.\nSince arriving in Singapore in late November, Collins said he had connected with mutual friends, largely through the NBA network, who have been generous to him and his family, including by hosting them for Thanksgiving dinner and offering them a place to stay in exchange for dog-sitting.\nAside from getting tired more frequently, Collins has been well enough to explore the city state and try local foods like chilli crab and even clocked a two-hour walk around Orchard Road and the Singapore Botanic Gardens on Sunday and spent a few days in a resort in Bintan, Indonesia, for his and Green’s birthdays.\n“It’s kind of funny, because a lot of people, if they were just looking at my Instagram, would think we’re on a food tour,” he says.\nCollins’ current demeanour is a far cry from his condition in mid-August when he was struggling with short-term memory “like Dory in Finding Nemo”, he said, and in September when he described himself as “basically a vegetable”.\n\n“We didn’t know if he would ever come back,” said Green, as he recounted a cognitive test Collins underwent after his biopsy in Los Angeles, when he was not able to name a tennis racquet on a picture card despite being an avid player and fan of the sport. “It was really scary for us.”\nSince the news broke of his diagnosis last week, Collins said his phone had been blowing up, largely with supportive messages and suggestions for treatments and specialists. He likened the experience to when he first came out in 2013.\n“Since 2013, when I came out, I would rather just be open and say, this is what I’m going through, this is what I’m dealing with and if you can help somebody along the way, great. I always try to help,” said Collins, who attributed his ability to be open to his support system.\nMacDiarmid told This Week in Asia that compassionate cases like Collins’ gave EnGeneIC important data going into clinical trials, including a trial for GBM that she hoped would begin in Singapore in January or February next year. The company has opened a subsidiary in the city state.\n“This data from compassionate cases… gives us good signals as to which tumours are potentially going to be responsive, and certainly we are very interested in [GBM], because we’ve got a couple of patients here and in Singapore who are all doing well,” she said, lauding Singapore’s Health Sciences Authority for being very open to helping people at the end stage of their life.\nMacDiarmid said the goal for EnGeneIC was to get the treatment approved for the mass market quickly, which could take about two years.\nPresident of the Brain Tumour Society (Singapore) Melissa Lim said that it took “superhuman effort” from all involved to bring an experimental treatment like EDVs into Singapore. “Every line of them had the determination to bring it in, and people are now coming to Singapore for EnGeneIC, like Jason.”\n\nLim noted that the statistics were stacked against survivors, and in her 20 years of experience in GBM cases, she had only come across two who lived more than five years after they were diagnosed. According to the Glioblastoma Research Organisation, GBM’s median survival rate for adults is 14.6 months.\n“I’ve come to the point that each heartbreak has led to a result that this has to stop, something’s got to be done about it, it’s broken to the point where it’s grown into a determination,” said Lim, whose society supports some 300 families in Singapore.\nAside from Collins, another patient receiving the EDV treatment for his brain cancer is a 74-year-old man who preferred to remain anonymous.\nHis wife told This Week in Asia that since her husband began treatment in September at his doctor’s recommendation, he had his appetite return, and was able to get up from bed himself and shave himself in about five minutes.\nShe noticed a drastic change in her husband’s condition within the first few weeks of trying the therapy in terms of his tiredness and ability to do things on his own.\n“Each week, I can see the improvement. It’s given us a window of hope,” the carer said.\n</p>
<div class="lb-trans"><p>当 NBA 老将杰森·柯林斯在 5 月与他的长期伴侣布伦森·格林结婚时，六个月后因接受四期脑癌的实验性治疗而不得不将蜜月转移到新加坡，这并不在他的计划之内。\n 这位身高 2.13 米（7 英尺）的前中锋，47 岁，与电影制片人格林上个月在这个城市国家度过了感恩节，远离他们的大家庭，因为柯林斯正在接受他在与最具侵袭性脑癌作斗争时的第一剂 EDV（EnGeneIC Dream Vector）治疗。\n 上周四，柯林斯，第一位在美国主要职业体育联盟中公开出柜的男性，宣布他在 8 月 30 日被诊断为四期多形性胶质母细胞瘤（GBM），并正在新加坡的一家诊所接受创新治疗，他在 “48 小时内” 获得了出于同情理由的批准。\n 医生告诉柯林斯，如果他对癌症不采取任何措施，他在 NBA 打了 13 个赛季，将在六周到三个月内死亡。\n 柯林斯在接受《亚洲这一周》采访时谈到他在享受新婚生活时对诊断的感受，微笑着说：“这就是生活。”\n“生活是如此复杂，消耗负能量的精力，为什么呢？让我们尝试帮助，保持积极，把人们聚在一起，” 他在 EDV 治疗通过静脉注入到他血液中时，笑着补充道。\n 柯林斯目前正在新加坡的库里肿瘤学中心进行为期八周的实验性癌症治疗，由生物制药公司 EnGeneIC 提供，该公司使用抗体靶向的细菌衍生纳米细胞，这些细胞具有坚硬的细胞壁，可以通过肿瘤周围渗漏的血管进入肿瘤。\n 每个纳米细胞都充满了可以杀死癌细胞的高效毒性物质。当纳米细胞锁定癌细胞并被其吞噬时，癌细胞内部的毒性物质会迅速释放并杀死它——就像特洛伊木马一样。\n“感觉就像你打了一针非常强的流感疫苗，我能感觉到我的免疫系统在识别体内注入了某种东西。所以你会感到非常潮红，像发烧一样，感到疲惫，血压稍微升高，但除此之外，感觉并不糟糕，” 柯林斯说，而他的丈夫格林则指出，副作用远没有传统化疗那么毒性。\n 这对夫妇是通过柯林斯的一位高中朋友了解到 EDV 的。在格林联系了 EnGeneIC 的创始人后，新加坡很快被确定为获得治疗的最快途径。\nEnGeneIC 的联合创始人詹妮弗·麦克迪亚米德在电话采访中告诉《亚洲这一周》：“他与许多不同潜在疗法的人交谈过，最终找到了我们。他自己的医生并不热衷于进行实验性治疗，直到他经历了整个第一线和第二线治疗，但到那时，面对这种疾病，人们可能会死亡。他们可能完全没有反应。”\n 柯林斯同意说：“美国的医疗系统没有这里的反应快。”\n 当被问及是否很难决定在有限的时间内离开家时，他说：“这很困难，但仔细想想，这毫无疑问，因为你不想只是呆在家里。我爱我的家人，但我想尝试延长时间……我知道衰退的情况，以及它发生得有多快，所以我不想那样，必须在两者之间做点什么。”\n 目前，除了 EDV 治疗外，柯林斯还在接受一系列治疗，他和格林通过与其他护理人员和医疗专家交谈进行研究，同时利用人工智能筛选公开可用的数据。\n 他们前往马来西亚的吉隆坡获取一种电容癌症治疗设备，该设备使用低频、低强度的静电场来靶向和摧毁癌细胞。他还在服用抗抑郁药 Brintellix 和靶向癌症治疗药物 Avastin，这大大改善了柯林斯在 9 月的状况。\n 自 11 月底抵达新加坡以来，柯林斯表示，他与通过 NBA 网络的共同朋友建立了联系，他们对他和他的家人非常慷慨，包括为他们举办感恩节晚餐，并提供住宿以换取照看狗。\n 除了更频繁地感到疲惫外，柯林斯的身体状况良好，能够探索这个城市国家，尝试当地美食，如辣椒螃蟹，甚至在周日围绕乌节路和新加坡植物园走了两个小时，并在印尼的民丹岛度过了几天，为他和格林庆祝生日。\n“这有点好笑，因为很多人，如果他们只是看我的 Instagram，会认为我们在进行美食之旅，” 他说。\n 柯林斯目前的状态与他在 8 月中旬的状况截然不同，当时他在短期记忆方面挣扎，“就像《海底总动员》中的多莉”，他说，而在 9 月时他形容自己 “基本上是个植物人”。\n\n“我们不知道他是否会恢复，” 格林回忆起柯林斯在洛杉矶进行活检后接受的认知测试时说，当时他无法在图片卡上说出网球拍的名称，尽管他是这项运动的狂热爱好者和粉丝。“这对我们来说真的很可怕。”\n 自从上周他的诊断消息传出以来，柯林斯表示他的手机一直在响，主要是支持信息和治疗及专家的建议。他将这种经历比作他在 2013 年首次出柜时的感受。\n“自 2013 年我出柜以来，我宁愿坦诚地说，这是我正在经历的事情，这是我正在处理的事情，如果你能在这个过程中帮助某人，那就太好了。我总是尝试帮助，” 柯林斯说，他将自己能够坦诚的能力归功于他的支持系统。\n 麦克迪亚米德告诉《亚洲这一周》，像柯林斯这样的同情案例为 EnGeneIC 在临床试验中提供了重要数据，包括她希望明年 1 月或 2 月在新加坡开始的 GBM 试验。该公司在新加坡开设了子公司。\n“来自同情案例的数据……为我们提供了良好的信号，表明哪些肿瘤可能会对治疗产生反应，当然我们对 GBM 非常感兴趣，因为我们在这里和新加坡有几个患者都在良好恢复，” 她说，并赞扬新加坡的卫生科学局非常乐于帮助生命末期的人们。\n 麦克迪亚米德表示，EnGeneIC 的目标是尽快获得治疗的市场批准，这可能需要大约两年时间。\n 新加坡脑肿瘤协会主席梅丽莎·林表示，所有参与者都付出了 “超人般的努力”，将像 EDV 这样的实验性治疗引入新加坡。“他们每一条线都有决心将其引入，现在人们正在前往新加坡接受 EnGeneIC 的治疗，就像杰森一样。”\n\n 林指出，生存者的统计数据并不乐观，在她 20 年的 GBM 病例经验中，她只遇到过两例在被诊断后活过五年的患者。根据胶质母细胞瘤研究组织的数据，GBM 成年人的中位生存率为 14.6 个月。\n“我已经到了每一次心碎都导致结果的地步，这必须停止，必须对此采取行动，它已经坏到需要决心的地步，” 林说，她的协会在新加坡支持约 300 个家庭。\n 除了柯林斯，另一位接受 EDV 治疗的脑癌患者是一位 74 岁的男性，他希望保持匿名。\n 他的妻子告诉《亚洲这一周》，自从她的丈夫在医生的建议下于 9 月开始治疗以来，他的食欲恢复了，能够自己起床并在大约五分钟内剃须。\n 她注意到，在尝试治疗的头几周内，她丈夫的状况发生了显著变化，无论是在疲惫感还是独立能力方面。\n“每周，我都能看到改善。这给了我们希望的窗口，” 这位护理人员说。</p>
</div>

前 NBA 明星在新加坡接受脑癌治疗，充满希望地表示——‘让我们保持积极’