<div id="readability-page-1">By Bhanvi Satija and Maggie Fick LONDON, Feb 13 (Reuters) - Sanofi's incoming CEO, 65-year-old Belén Garijo, faces a major task to win over investors, accelerate the French company's stalled drug development pipeline and navigate vaccine scepticism in the United States under President Donald Trump. Investors, analysts and other people close to Garijo, who has headed Germany's Merck KGaA since 2021, told Reuters she was bold, detail-focused and got things done, but also that she had a mixed record on R&amp;D and the share ​price had dropped during her tenure. Sanofi's stock, down 25% in the last year, fell 3.5% on ‌Thursday after it said CEO Paul Hudson, 58, whose turnaround drive was stymied by a lack of new blockbuster drugs, would step down this month to be replaced by Garijo in April. &#34;The CEO change at Sanofi is a sign ⁠that R&amp;D transformation has failed or is happening too slowly,&#34; said Markus Manns, portfolio manager at Sanofi investor Union Investment. &#34;Belen's priority at Sanofi will be to increase ⁠R&amp;D productivity.&#34; Manns lauded Spaniard Garijo's handling of a complex company - Merck has units from health to technology - and a pricing ‌deal sealed with U.S. President Donald Trump ‌last year, but said she needed to step up after several R&amp;D failures at Merck. &#34;She needs to improve her R&amp;D track record.&#34; REPLACING ASTHMA BLOCKBUSTER DUPIXENT IS A MAJOR CHALLENGE Developing new drugs has proved to be Sanofi's biggest ​issue. Dupixent accounts for over 30% of the company's revenues and it has yet to ‌find a drug to take over once patents begin expiring early in the 2030s, which has weighed on Sanofi's share price. &#34;Replacing Dupixent is the key strategic challenge for Sanofi,&#34; said Nicolas Dumas, a partner at consultancy firm Roland Berger and a Sanofi employee until 2018. Vaccines, which make up ​close to a fifth of revenues, are another major issue as sales have ​dipped in recent years. ‌Hudson had flagged weakness in the segment linked to a more hostile attitude towards vaccines from the U.S. health administration. Sanofi said Garijo, who worked at the French company for years until 2011, would bring &#34;increased rigour to the implementation of&#34; the company's strategy. Garijo did not immediately respond to requests for ⁠comment. SHE WILL BECOME SANOFI'S FIRST FEMALE CEO Garijo will be Sanofi's first female CEO - and the only woman CEO at a large-cap global drugmaker after GSK's Emma ⁠Walmsley stepped down this year. She was the first woman to head a German DAX-listed company when she took on the top role at Merck KGaA. As head of Merck's pharma business, Garijo steered the group's supply chain through the COVID-19 pandemic. She oversaw deals including the group's $3.9 billion purchase of SpringWorks Therapeutics last year. However, Merck KGaA suffered setbacks in drug development during her tenure and only three new drugs made it to the market. One investor who worked with Garijo, asking not to be named, said the &#34;visible stuff&#34; - R&amp;D and ⁠business development - had ‌not gone well, while adding she had improved the structure of Merck internally and protected the company's margins. Roel Bulthuis, managing ‌partner at Syncona Limited, a London-based life sciences investment firm, said that Garijo had turned a company &#34;stuck in rules and hierarchy&#34; into a much more bold and effective entity. &#34;She... challenged ⁠executives to have guts to stand up for their decisions and actually get shit done,&#34; said Bulthuis, who previously ran M-Ventures, the corporate venture fund of Merck KGaA, during part of Garijo's tenure. A second investor who worked with Garijo said she was full of energy, dynamic and &#34;on top of things&#34; and also had deep knowledge of Sanofi. &#34;She knows the house, don't underestimate the importance of that,&#34; said the person, who also asked not to be named. CLINICAL BACKGROUND, BUT HOW LONG WILL SHE STAY? A clinical pharmacology specialist, Garijo began her career as a physician at La Paz Hospital in Madrid and is known for her operational execution and attention to detail. Garijo has &#34;more operations experience than a science background, so will be interesting to see how she can reinvigorate the ​R&amp;D department in Sanofi,&#34; said Claus Henrik Johansen, CEO of Global Health Invest, a Danish healthcare investment fund that holds Sanofi shares. Some analysts and investors said Garijo had not been on many people's radar, which caught the market slightly by surprise - and they speculated how long she would stay in her new job. &#34;I think she's a transition CEO. What ​she's good at, she's someone who can put the organisation under pressure,&#34; ‌consultant Dumas said. &#34;She's not there to stay forever.&#34; (Reporting by Bhanvi Satija and Maggie Fick in London, Patricia Weiss and Ludwig ​Burger in Frankfurt; Editing by Adam Jourdan and Barbara Lewis)</div>

IBBQ

标普全球医疗股指数 ETF - iShares

生物科技 ETF - VanEck Vectors

赛诺菲的新任首席执行官贝伦·加里霍面临着重振公司药物管线和应对美国特朗普总统任内疫苗怀疑主义的重大挑战。由于赛诺菲的股价在过去一年下跌了 25%，加里霍必须提高研发生产力，并替代目前占销售额超过 30% 的 Dupixent 的收入。作为全球主要制药公司首位女性首席执行官，她的运营专长将至关重要，但她的研发记录参差不齐，引发了对她有效领导能力的质疑。分析师推测她可能是一个过渡性人物，而非长期解决方案

Analysis-Sanofi's new CEO needs to fix drug pipeline and navigate Trump

fidelity

Invesco Nasdaq Biotechnology ETF

纽交所高增长板生物技术指数 ETF - First Trust

基因改革 ETF - ARK

纳斯达克生物科技指数 ETF - iShares Nasdaq

美国制药 ETF - iShares

医药突破 ETF - ALPS

赛诺菲集团

2 倍做多纳斯达克生物技术 ETF - ProShares

标普生物技术 ETF - SPDR

医疗业 ETF - Vanguard

医疗业 ETF - SPDR

动态生物技术与基因组 ETF - Invesco

赛诺菲

分析 - 赛诺菲的新任首席执行官需要修复药物研发管线并应对特朗普的挑战