<div id="readability-page-1"><div>Volastra Therapeutics Announces Biomarker and Combination Data around AACR 2026 Defining an Rb Pathway-Driven Pan-Cancer Development Strategy for KIF18A Inhibitors<ul> <li> p16 Loss – a marker of Rb pathway inactivation – Identified as a Candidate Predictive Biomarker for KIF18A Inhibition </li> <li> Data Support Development Across Multiple Tumor Types and in Combination with Standard Therapies </li> </ul> Volastra Therapeutics, a clinical-stage oncology company pioneering therapies targeting chromosomal instability (CIN), today announced multiple scientific disclosures coinciding with the American Association for Cancer Research (AACR) Annual Meeting 2026, taking place April 17–22 in San Diego, California. The data define an Rb pathway–driven pan-cancer development framework for KIF18A inhibitors and highlight a proprietary p16 IHC biomarker approach designed to translate that strategy clinically, reinforcing Volastra’s leadership in advancing CIN biology into therapeutic opportunity. Separate from its AACR 2026 presentation, Volastra has posted “KIF18A Inhibition as a Therapeutic Strategy in Cancers with Rb Pathway Inactivation” (Andreu et al. DOI: https://zenodo.org/records/19616790 - preprint publication). Drawing on what is believed to be one of the largest datasets of its kind, the work identifies Rb pathway inactivation as the mechanistic basis of response to KIF18A inhibition and establishes a development path that extends well beyond high-grade serous ovarian cancer. The study includes clinical data from a substantial cohort of 79 heavily pretreated patients with high-grade serous ovarian cancer treated with either of two distinct KIF18A inhibitors, sovilnesib and VLS-1488. The concordance of the biomarker-defined signal across both agents is particularly compelling and argues against a drug-specific observation. Biomarker-positive tumors were distinguished by marked enrichment for objective responses, durable disease control, and longer progression-free survival, yielding a sharp clinical separation from biomarker-negative disease and strongly supporting both the biomarker strategy and prospective clinical development. These findings reposition KIF18A inhibition from a histology-defined opportunity into a pan-cancer synthetic lethal strategy centered on one of the most commonly disrupted tumor suppressor pathways in human cancer. This creates a credible path across what is estimated to represent approximately 15% of human cancers. Within that biology, Volastra has identified a proprietary p16 IHC biomarker strategy that enriches for response to its KIF18A inhibitors and provides a practical route to clinical translation. “The data provide a strong scientific rationale for using p16 status to identify patients most likely to benefit from KIF18A inhibition,” said David Southwell, Chief Executive Officer of Volastra Therapeutics. “Importantly, this work reframes KIF18A inhibition from a narrow single cancer-type opportunity into a broader pan-cancer strategy grounded in Rb pathway biology. This p16 biomarker approach provides a practical way to translate that insight into clinical development and patient selection.” AACR Poster Highlights Clear Synergy with Taxanes and Other Microtubule-Targeting Agents Volastra will also present an official AACR poster titled “Combination of VLS-1488 and taxanes induces anti-tumor synergistic effect in cancer cells” in the Experimental and Molecular Therapeutics, Novel Antitumor Agents 1 Session on April 19 from 2-5PM Pacific Time (PT) (Poster section 17, poster 18). The presentation will highlight preclinical combination data showing clear synergistic activity between KIF18A inhibition and taxanes and other microtubule-targeting agents. These findings support a development strategy that could extend KIF18A inhibitors into earlier lines of therapy, including combination approaches in frontline settings. “The totality of these data help define both the monotherapy and combination development paths for KIF18A inhibitors,” said Samuel F. Bakhoum, M.D., Ph.D., Co-Founder and Chief Scientific Officer of Volastra Therapeutics. “With this new mechanistic understanding of KIF18A inhibitor sensitivity, it is evident that the biomarker data will help us identify patients most likely to benefit from monotherapy, while the combination findings point to a precision-based approach to identify the most rational therapeutic partners for development in earlier line settings.” Separately, Dr. Bakhoum, also an adjunct faculty member at the Geisel School of Medicine at Dartmouth, will chair an AACR educational session “Chromosomal Instability in Cancer: From Mechanism to Therapy and Clinical Translation” on Saturday, April 18, 2026, in his academic capacity. The session reflects the field’s growing appreciation of CIN as both a driver of aggressive disease and a source of therapeutic vulnerability. “This momentum underscores the growing recognition of CIN biology and the increasing importance of CIN-directed therapeutic strategies across oncology,” Dr. Bakhoum said. About Volastra Therapeutics Volastra Therapeutics is a New York-based clinical-stage biotechnology company pioneering novel approaches to treating cancer by targeting tumor vulnerability known as chromosomal instability, or CIN. The company was founded in 2019 by Samuel Bakhoum, M.D., Ph.D., Lewis Cantley, Ph.D., and Olivier Elemento, Ph.D., and is funded by Eli Lilly &amp; Company, B Capital, ARCH Venture Partners, Polaris Partners, Droia Ventures, Vida Ventures, and Catalio Capital Management. Volastra is developing new approaches to understand the biology of chromosomal instability and applying those insights to drive a pipeline of therapies against novel targets. The company leads the field with two differentiated clinical-stage KIF18A inhibitors, VLS-1488 and sovilnesib, formerly AMG-650, along with a robust discovery pipeline. For more information, please visit www.volastratx.com. <img src="https://imageproxy.pbkrs.com/https://cts.businesswire.com/ct/CT/query-ZGlzdHJvPW54JmlkPWJ3bmV3cyZsYW5nPWVuJnNpZD1tc3RyMyZzdHk9MjAyNjA0MTc4ODY2MjNyMQ?x-oss-process=image/auto-orient,1/interlace,1/resize,w_1440,h_1440/quality,q_95/format,jpg" original-src="https://imageproxy.pbkrs.com/https://cts.businesswire.com/ct/CT/query-ZGlzdHJvPW54JmlkPWJ3bmV3cyZsYW5nPWVuJnNpZD1tc3RyMyZzdHk9MjAyNjA0MTc4ODY2MjNyMQ"/> Investor Relations/Media Contact: Sasha Damouni Damouni Group, LLC. sasha@damounigroup.com View source version on businesswire.com: https://www.businesswire.com/news/home/20260417886623/en/</div></div>

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Volastra Therapeutics 宣布了与 KIF18A 抑制剂相关的重要发现，提前发布于 2026 年 AACR 年会。该公司确定了 p16 缺失作为 KIF18A 抑制的预测生物标志物，支持其在多种肿瘤类型中的开发。数据表明，基于 Rb 通路生物学的全癌症策略具有前景，来自一项涉及重度预处理卵巢癌患者的研究结果令人鼓舞。此外，临床前数据表明 KIF18A 抑制剂与紫杉烷之间存在协同作用，显示出早期治疗的潜力。Volastra 旨在利用这些见解进行临床开发和患者选择

Volastra Therapeutics Announces Biomarker and Combination Data around AACR 2026 Defining an Rb Pathway-Driven Pan-Cancer Development Strategy for KIF18A Inhibitors

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Volastra Therapeutics 宣布在 AACR 2026 会议上，围绕 Rb 通路驱动的 KIF18A 抑制剂的泛癌症开发策略，发布了生物标志物和组合数据