<p>RNS 編號：1082U PureTech Health PLC2025 年 8 月 5 日</p>
<p>TR-1：主要持股通知的標準表格</p>
<p>1. 發行人詳情</p>
<p>ISIN</p>
<p>GB00BY2Z0H74</p>
<p>發行人名稱</p>
<p>PURETECH HEALTH PLC</p>
<p>英國或非英國發行人</p>
<p>英國</p>
<p>2. 通知原因</p>
<p>投票權結構發生變化的事件</p>
<p>3. 受通知義務的人的詳細信息</p>
<p>姓名</p>
<p>Invesco Ltd.</p>
<p>註冊辦公室所在城市（如適用）</p>
<p>亞特蘭大</p>
<p>註冊辦公室所在國家（如適用）</p>
<p>美國</p>
<p>4. 股東的詳細信息</p>
<p>如果與上述受通知義務的個人不同，股東的全名</p>
<p>註冊辦公室所在城市（如適用）</p>
<p>註冊辦公室所在國家（如適用）</p>
<p>5. 超過或達到閾值的日期</p>
<p>2025 年 8 月 1 日</p>
<p>6. 發行人通知的日期</p>
<p>2025 年 8 月 5 日</p>
<p>7. 受通知義務的人的總持倉</p>
<table>
<thead>
<tr>
<th></th>
<th></th>
<th></th>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td></td>
<td>附加於股份的投票權百分比（8.A 總計）</td>
<td>通過金融工具的投票權百分比（8.B 1 + 8.B 2 總計）</td>
<td>兩者總和的百分比（8.A + 8.B）</td>
<td>發行人持有的投票權總數</td>
</tr>
<tr>
<td>超過或達到閾值時的結果情況</td>
<td>16.995075</td>
<td>0.000000</td>
<td>16.995075</td>
<td>41011890</td>
</tr>
<tr>
<td>之前通知的持倉情況（如適用）</td>
<td>17.142104</td>
<td>0.161018</td>
<td>17.303122</td>
<td></td>
</tr>
</tbody>
</table>
<p>8. 超過或達到閾值時的結果情況的通知詳情</p>
<p>8A. 附加於股份的投票權</p>
<table>
<thead>
<tr>
<th></th>
<th></th>
<th></th>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>股份類別/類型 ISIN 代碼（如可能）</td>
<td>直接投票權數量（DTR5.1）</td>
<td>間接投票權數量（DTR5.2.1）</td>
<td>直接投票權的百分比（DTR5.1）</td>
<td>間接投票權的百分比（DTR5.2.1）</td>
</tr>
<tr>
<td>GB00BY2Z0H74</td>
<td></td>
<td>41011890</td>
<td></td>
<td>16.995075</td>
</tr>
<tr>
<td>小計 8.A</td>
<td>41011890</td>
<td>16.995075%</td>
<td></td>
<td></td>
</tr>
</tbody>
</table>
<p>8B1. 根據 (DTR5.3.1R.(1) (a)) 的金融工具</p>
<table>
<thead>
<tr>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>金融工具類型</td>
<td>小計 8.B1</td>
</tr>
<tr>
<td>到期日期</td>
<td></td>
</tr>
<tr>
<td>行使/轉換期限</td>
<td></td>
</tr>
<tr>
<td>如果行使/轉換該工具可獲得的投票權數量</td>
<td></td>
</tr>
<tr>
<td>投票權的百分比</td>
<td></td>
</tr>
</tbody>
</table>
<p>8B2. 根據 (DTR5.3.1R.(1) (b)) 具有類似經濟效果的金融工具</p>
<table>
<thead>
<tr>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>金融工具類型</td>
<td>小計 8.B2</td>
</tr>
<tr>
<td>到期日期</td>
<td></td>
</tr>
<tr>
<td>行使/轉換期限</td>
<td></td>
</tr>
<tr>
<td>實物或現金結算</td>
<td></td>
</tr>
<tr>
<td>投票權數量</td>
<td></td>
</tr>
<tr>
<td>投票權的百分比</td>
<td></td>
</tr>
</tbody>
</table>
<p>9. 關於受通知義務的人的信息</p>
<p>2. 通過最終控制自然人或法律實體有效持有投票權和/或金融工具的受控企業的完整鏈條（如有必要，請添加額外行）</p>
<table>
<thead>
<tr>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>最終控制人</td>
<td>Invesco Ltd.</td>
</tr>
<tr>
<td>受控企業名稱</td>
<td>Invesco Asset Management Limited</td>
</tr>
<tr>
<td>如果等於或高於可通知閾值的投票權百分比</td>
<td>16.995075</td>
</tr>
<tr>
<td>如果等於或高於可通知閾值的通過金融工具的投票權百分比</td>
<td>0.000000</td>
</tr>
<tr>
<td>如果等於或高於可通知閾值的兩者總和</td>
<td>16.995075%</td>
</tr>
</tbody>
</table>
<p>10. 在代理投票的情況下</p>
<p>代理持有人姓名</p>
<p>持有的投票權數量和百分比</p>
<p>持有投票權的截止日期</p>
<p>11. 附加信息</p>
<p>請注意，由於投票權總數的變化，披露閾值已被超過。有關代理持有人及其持有的投票權百分比的詳細信息，請參閲第 9 節。投票權的授權在客户撤銷或相關投資管理協議終止之前有效。</p>
<p>12. 完成日期</p>
<p>2025 年 8 月 5 日</p>
<p>13. 完成地點</p>
<p>亨利河畔泰晤士</p>
<p>此信息由 RNS 提供，RNS 是倫敦證券交易所的新聞服務。RNS 獲得金融行為監管局的批准，作為英國的主要信息提供者。有關使用和分發此信息的條款和條件可能適用。有關更多信息，請聯繫 rns@lseg.com 或訪問 www.rns.com。</p>
<p>RNS 可能會使用您的 IP 地址以確認遵守條款和條件，分析您與本通信中包含的信息的互動，並在我們的商業服務中以匿名方式與他人共享此類分析。有關 RNS 和倫敦證券交易所如何使用您提供的個人數據的更多信息，請參見我們的隱私政策。結束 HOLPAMFTMTBMBAA</p>

景順投資管理

PRTC

<p>PureTech Health PLC 宣佈主要持股發生變動，景順投資管理於 2025 年 8 月 1 日超過了通知閾值。景順目前持有該公司 16.995075% 的投票權，較之前的 17.142104% 有所下降。該通知於 2025 年 8 月 5 日發佈，因總投票權發生變化。該信息由倫敦證券交易所的新聞服務 RNS 提供</p>

<p>RNS Number : 1082U PureTech Health PLC 05 August 2025</p>
<div class="lb-trans"><p>RNS 編號：1082U PureTech Health PLC2025 年 8 月 5 日</p>
</div><p>TR-1: Standard form for notification of major holdings</p>
<div class="lb-trans"><p>TR-1：主要持股通知的標準表格</p>
</div><p>1. Issuer Details</p>
<div class="lb-trans"><p>1. 發行人詳情</p>
</div><p>ISIN</p>
<div class="lb-trans"><p>ISIN</p>
</div><p>GB00BY2Z0H74</p>
<div class="lb-trans"><p>GB00BY2Z0H74</p>
</div><p>Issuer Name</p>
<div class="lb-trans"><p>發行人名稱</p>
</div><p>PURETECH HEALTH PLC</p>
<div class="lb-trans"><p>PURETECH HEALTH PLC</p>
</div><p>UK or Non-UK Issuer</p>
<div class="lb-trans"><p>英國或非英國發行人</p>
</div><p>UK</p>
<div class="lb-trans"><p>英國</p>
</div><p>2. Reason for Notification</p>
<div class="lb-trans"><p>2. 通知原因</p>
</div><p>An event changing the breakdown of voting rights</p>
<div class="lb-trans"><p>投票權結構發生變化的事件</p>
</div><p>3. Details of person subject to the notification obligation</p>
<div class="lb-trans"><p>3. 受通知義務的人的詳細信息</p>
</div><p>Name</p>
<div class="lb-trans"><p>姓名</p>
</div><p>Invesco Ltd.</p>
<div class="lb-trans"><p>Invesco Ltd.</p>
</div><p>City of registered office (if applicable)</p>
<div class="lb-trans"><p>註冊辦公室所在城市（如適用）</p>
</div><p>Atlanta</p>
<div class="lb-trans"><p>亞特蘭大</p>
</div><p>Country of registered office (if applicable)</p>
<div class="lb-trans"><p>註冊辦公室所在國家（如適用）</p>
</div><p>USA</p>
<div class="lb-trans"><p>美國</p>
</div><p>4. Details of the shareholder</p>
<div class="lb-trans"><p>4. 股東的詳細信息</p>
</div><p>Full name of shareholder(s) if different from the person(s) subject to the notification obligation, above</p>
<div class="lb-trans"><p>如果與上述受通知義務的個人不同，股東的全名</p>
</div><p>City of registered office (if applicable)</p>
<div class="lb-trans"><p>註冊辦公室所在城市（如適用）</p>
</div><p>Country of registered office (if applicable)</p>
<div class="lb-trans"><p>註冊辦公室所在國家（如適用）</p>
</div><p>5. Date on which the threshold was crossed or reached</p>
<div class="lb-trans"><p>5. 超過或達到閾值的日期</p>
</div><p>01-Aug-2025</p>
<div class="lb-trans"><p>2025 年 8 月 1 日</p>
</div><p>6. Date on which Issuer notified</p>
<div class="lb-trans"><p>6. 發行人通知的日期</p>
</div><p>05-Aug-2025</p>
<div class="lb-trans"><p>2025 年 8 月 5 日</p>
</div><p>7. Total positions of person(s) subject to the notification obligation</p>
<div class="lb-trans"><p>7. 受通知義務的人的總持倉</p>
</div><table>
<thead>
<tr>
<th></th>
<th></th>
<th></th>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td></td>
<td>% of voting rights attached to shares (total of 8.A)</td>
<td>% of voting rights through financial instruments (total of 8.B 1 + 8.B 2)</td>
<td>Total of both in % (8.A + 8.B)</td>
<td>Total number of voting rights held in issuer</td>
</tr>
<tr>
<td>Resulting situation on the date on which threshold was crossed or reached</td>
<td>16.995075</td>
<td>0.000000</td>
<td>16.995075</td>
<td>41011890</td>
</tr>
<tr>
<td>Position of previous notification (if applicable)</td>
<td>17.142104</td>
<td>0.161018</td>
<td>17.303122</td>
<td></td>
</tr>
</tbody>
</table>
<div class="lb-trans"><table>
<thead>
<tr>
<th></th>
<th></th>
<th></th>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td></td>
<td>附加於股份的投票權百分比（8.A 總計）</td>
<td>通過金融工具的投票權百分比（8.B 1 + 8.B 2 總計）</td>
<td>兩者總和的百分比（8.A + 8.B）</td>
<td>發行人持有的投票權總數</td>
</tr>
<tr>
<td>超過或達到閾值時的結果情況</td>
<td>16.995075</td>
<td>0.000000</td>
<td>16.995075</td>
<td>41011890</td>
</tr>
<tr>
<td>之前通知的持倉情況（如適用）</td>
<td>17.142104</td>
<td>0.161018</td>
<td>17.303122</td>
<td></td>
</tr>
</tbody>
</table>
</div><p>8. Notified details of the resulting situation on the date on which the threshold was crossed or reached</p>
<div class="lb-trans"><p>8. 超過或達到閾值時的結果情況的通知詳情</p>
</div><p>8A. Voting rights attached to shares</p>
<div class="lb-trans"><p>8A. 附加於股份的投票權</p>
</div><table>
<thead>
<tr>
<th></th>
<th></th>
<th></th>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>Class/Type of shares ISIN code(if possible)</td>
<td>Number of direct voting rights (DTR5.1)</td>
<td>Number of indirect voting rights (DTR5.2.1)</td>
<td>% of direct voting rights (DTR5.1)</td>
<td>% of indirect voting rights (DTR5.2.1)</td>
</tr>
<tr>
<td>GB00BY2Z0H74</td>
<td></td>
<td>41011890</td>
<td></td>
<td>16.995075</td>
</tr>
<tr>
<td>Sub Total 8.A</td>
<td>41011890</td>
<td>16.995075%</td>
<td></td>
<td></td>
</tr>
</tbody>
</table>
<div class="lb-trans"><table>
<thead>
<tr>
<th></th>
<th></th>
<th></th>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>股份類別/類型 ISIN 代碼（如可能）</td>
<td>直接投票權數量（DTR5.1）</td>
<td>間接投票權數量（DTR5.2.1）</td>
<td>直接投票權的百分比（DTR5.1）</td>
<td>間接投票權的百分比（DTR5.2.1）</td>
</tr>
<tr>
<td>GB00BY2Z0H74</td>
<td></td>
<td>41011890</td>
<td></td>
<td>16.995075</td>
</tr>
<tr>
<td>小計 8.A</td>
<td>41011890</td>
<td>16.995075%</td>
<td></td>
<td></td>
</tr>
</tbody>
</table>
</div><p>8B1. Financial Instruments according to (DTR5.3.1R.(1) (a))</p>
<div class="lb-trans"><p>8B1. 根據 (DTR5.3.1R.(1) (a)) 的金融工具</p>
</div><table>
<thead>
<tr>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>Type of financial instrument</td>
<td>Sub Total 8.B1</td>
</tr>
<tr>
<td>Expiration date</td>
<td></td>
</tr>
<tr>
<td>Exercise/conversion period</td>
<td></td>
</tr>
<tr>
<td>Number of voting rights that may be acquired if the instrument is exercised/converted</td>
<td></td>
</tr>
<tr>
<td>% of voting rights</td>
<td></td>
</tr>
</tbody>
</table>
<div class="lb-trans"><table>
<thead>
<tr>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>金融工具類型</td>
<td>小計 8.B1</td>
</tr>
<tr>
<td>到期日期</td>
<td></td>
</tr>
<tr>
<td>行使/轉換期限</td>
<td></td>
</tr>
<tr>
<td>如果行使/轉換該工具可獲得的投票權數量</td>
<td></td>
</tr>
<tr>
<td>投票權的百分比</td>
<td></td>
</tr>
</tbody>
</table>
</div><p>8B2. Financial Instruments with similar economic effect according to (DTR5.3.1R.(1) (b))</p>
<div class="lb-trans"><p>8B2. 根據 (DTR5.3.1R.(1) (b)) 具有類似經濟效果的金融工具</p>
</div><table>
<thead>
<tr>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>Type of financial instrument</td>
<td>Sub Total 8.B2</td>
</tr>
<tr>
<td>Expiration date</td>
<td></td>
</tr>
<tr>
<td>Exercise/conversion period</td>
<td></td>
</tr>
<tr>
<td>Physical or cash settlement</td>
<td></td>
</tr>
<tr>
<td>Number of voting rights</td>
<td></td>
</tr>
<tr>
<td>% of voting rights</td>
<td></td>
</tr>
</tbody>
</table>
<div class="lb-trans"><table>
<thead>
<tr>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>金融工具類型</td>
<td>小計 8.B2</td>
</tr>
<tr>
<td>到期日期</td>
<td></td>
</tr>
<tr>
<td>行使/轉換期限</td>
<td></td>
</tr>
<tr>
<td>實物或現金結算</td>
<td></td>
</tr>
<tr>
<td>投票權數量</td>
<td></td>
</tr>
<tr>
<td>投票權的百分比</td>
<td></td>
</tr>
</tbody>
</table>
</div><p>9. Information in relation to the person subject to the notification obligation</p>
<div class="lb-trans"><p>9. 關於受通知義務的人的信息</p>
</div><p>2. Full chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held starting with the ultimate controlling natural person or legal entities (please add additional rows as necessary)</p>
<div class="lb-trans"><p>2. 通過最終控制自然人或法律實體有效持有投票權和/或金融工具的受控企業的完整鏈條（如有必要，請添加額外行）</p>
</div><table>
<thead>
<tr>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>Ultimate controlling person</td>
<td>Invesco Ltd.</td>
</tr>
<tr>
<td>Name of controlled undertaking</td>
<td>Invesco Asset Management Limited</td>
</tr>
<tr>
<td>% of voting rights if it equals or is higher than the notifiable threshold</td>
<td>16.995075</td>
</tr>
<tr>
<td>% of voting rights through financial instruments if it equals or is higher than the notifiable threshold</td>
<td>0.000000</td>
</tr>
<tr>
<td>Total of both if it equals or is higher than the notifiable threshold</td>
<td>16.995075%</td>
</tr>
</tbody>
</table>
<div class="lb-trans"><table>
<thead>
<tr>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>最終控制人</td>
<td>Invesco Ltd.</td>
</tr>
<tr>
<td>受控企業名稱</td>
<td>Invesco Asset Management Limited</td>
</tr>
<tr>
<td>如果等於或高於可通知閾值的投票權百分比</td>
<td>16.995075</td>
</tr>
<tr>
<td>如果等於或高於可通知閾值的通過金融工具的投票權百分比</td>
<td>0.000000</td>
</tr>
<tr>
<td>如果等於或高於可通知閾值的兩者總和</td>
<td>16.995075%</td>
</tr>
</tbody>
</table>
</div><p>10. In case of proxy voting</p>
<div class="lb-trans"><p>10. 在代理投票的情況下</p>
</div><p>Name of the proxy holder</p>
<div class="lb-trans"><p>代理持有人姓名</p>
</div><p>The number and % of voting rights held</p>
<div class="lb-trans"><p>持有的投票權數量和百分比</p>
</div><p>The date until which the voting rights will be held</p>
<div class="lb-trans"><p>持有投票權的截止日期</p>
</div><p>11. Additional Information</p>
<div class="lb-trans"><p>11. 附加信息</p>
</div><p>Please note that the disclosure threshold was crossed due to a change in Total Voting rights. Refer to section 9 for detail of proxy holder's and % of voting rights held. Voting authority is held until it is revoked by the client/ the relevant Investment Management Agreement is terminated.</p>
<div class="lb-trans"><p>請注意，由於投票權總數的變化，披露閾值已被超過。有關代理持有人及其持有的投票權百分比的詳細信息，請參閲第 9 節。投票權的授權在客户撤銷或相關投資管理協議終止之前有效。</p>
</div><p>12. Date of Completion</p>
<div class="lb-trans"><p>12. 完成日期</p>
</div><p>05-Aug-2025</p>
<div class="lb-trans"><p>2025 年 8 月 5 日</p>
</div><p>13. Place Of Completion</p>
<div class="lb-trans"><p>13. 完成地點</p>
</div><p>Henley-on-Thames</p>
<div class="lb-trans"><p>亨利河畔泰晤士</p>
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<div class="lb-trans"><p>此信息由 RNS 提供，RNS 是倫敦證券交易所的新聞服務。RNS 獲得金融行為監管局的批准，作為英國的主要信息提供者。有關使用和分發此信息的條款和條件可能適用。有關更多信息，請聯繫 rns@lseg.com 或訪問 www.rns.com。</p>
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