<div id="readability-page-1"><div id="parent_top_div">India's drug regulator on Friday ordered state authorities to ensure all pharmaceutical factories comply with international manufacturing standards by January, rejecting industry pleas for more time after toxic cough syrup was linked to additional child deaths since September. The government had directed drugmakers in late 2023 to upgrade plants to World Health Organization-recommended norms, including measures to prevent cross-contamination and enable batch testing. The move followed global outrage after India-made cough syrups were tied to the deaths of more than 140 children in Africa and Central Asia, tarnishing the country's reputation as the &#34;pharmacy of the world.&#34; Large pharmaceutical firms met a June 2024 deadline, while smaller manufacturers were given until December 2025 as part of an earlier extension. Industry groups had sought further extensions, warning that compliance costs could bankrupt small businesses. But the deaths of 24 children in central India linked to contaminated syrup prompted authorities to hold firm. The Central Drugs Standard Control Organisation said in a notice, seen by Reuters, that the revised standards under &#34;Schedule M&#34; will apply to all manufacturers from January 1, and directed state regulators to begin inspections. &#34;In case any manufacturing unit is found non-complying with the requirements of revised Schedule M during inspections, strict action shall be initiated,&#34; the notice, signed by Drugs Controller General Rajeev Singh Raghuvanshi, said. Firms that do not fall under the extension criteria should be inspected immediately, the notice said. He asked states to treat the matter as a &#34;top priority&#34;. Raghuvanshi's office did not immediately respond to a request for a comment. Reuters reported exclusively on October 17 that no extension would be granted. However, an association representing small- and medium-sized drugmakers warned the mandate could shutter many factories, causing job losses and pushing up medicine prices. &#34;What good is quality if there is no affordability?&#34; said Jagdeep Singh, secretary of the SME Pharma Industries Confederation. </div></div>

印度藥品監管機構已要求所有制藥廠在一月份之前遵守國際生產標準，此舉是由於與有毒咳嗽糖漿相關的 140 多名兒童死亡事件。中央藥品標準控制組織強調，將開始嚴格檢查，不合規的製造商將面臨嚴厲後果。雖然大型企業已滿足早期截止日期，但小型製造商表示，合規成本可能導致破產和藥品價格上漲。政府已拒絕進一步延期的請求，優先考慮藥品生產的安全和質量

由於咳嗽糖漿致死事件，CDSCO 要求製藥商在一月前達到全球標準