<p>RNS 編號：6849K Hemogenyx Pharmaceuticals PLC2025 年 12 月 8 日</p>
<p>TR-1：主要持股通知的標準表格</p>
<ol>
<li>發行人詳情</li>
</ol>
<p>ISIN</p>
<p>GB00BQVXM815</p>
<p>發行人名稱</p>
<p>HEMOGENYX PHARMACEUTICALS PLC</p>
<p>英國或非英國發行人</p>
<p>英國</p>
<ol>
<li>通知原因</li>
</ol>
<p>投票權的收購或處置</p>
<ol>
<li>受通知義務約束的個人詳情</li>
</ol>
<p>姓名</p>
<p>David John Smith</p>
<p>註冊辦公室所在城市（如適用）</p>
<p>格里姆斯比</p>
<p>註冊辦公室所在國家（如適用）</p>
<p>英國</p>
<ol>
<li>股東詳情</li>
</ol>
<table>
<thead>
<tr>
<th></th>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>名稱</td>
<td>註冊辦公室所在城市</td>
<td>註冊辦公室所在國家</td>
</tr>
<tr>
<td>GHC Property Services Limited</td>
<td>格里姆斯比</td>
<td>英格蘭</td>
</tr>
<tr>
<td>Copier Systems Limited</td>
<td>斯肯索普</td>
<td>英格蘭</td>
</tr>
<tr>
<td>HBP Monpellier Limited</td>
<td>卡萊爾</td>
<td>英格蘭</td>
</tr>
<tr>
<td>Kamarin Computers Limited</td>
<td>斯肯索普</td>
<td>英格蘭</td>
</tr>
<tr>
<td>HBP Systems Limited</td>
<td>斯肯索普</td>
<td>英格蘭</td>
</tr>
<tr>
<td>Transact Nominees Limited</td>
<td>倫敦</td>
<td>英格蘭</td>
</tr>
<tr>
<td>Interactive Investor Services Nominees Limited</td>
<td>曼徹斯特</td>
<td>英格蘭</td>
</tr>
</tbody>
</table>
<ol>
<li>超過或達到閾值的日期</li>
</ol>
<p>2025 年 11 月 24 日</p>
<ol>
<li>發行人通知的日期</li>
</ol>
<p>2025 年 11 月 24 日</p>
<ol>
<li>受通知義務約束的個人的總持倉</li>
</ol>
<table>
<thead>
<tr>
<th></th>
<th></th>
<th></th>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td></td>
<td>附加於股份的投票權百分比（8.A 總計）</td>
<td>通過金融工具的投票權百分比（8.B 1 + 8.B 2 總計）</td>
<td>兩者總和的百分比（8.A + 8.B）</td>
<td>發行人持有的投票權總數</td>
</tr>
<tr>
<td>超過或達到閾值時的結果情況</td>
<td>6.750640</td>
<td>0.000000</td>
<td>6.750640</td>
<td>399478</td>
</tr>
<tr>
<td>之前通知的持倉情況（如適用）</td>
<td>5.163200</td>
<td>0.000000</td>
<td>5.163200</td>
<td></td>
</tr>
</tbody>
</table>
<ol>
<li>超過或達到閾值時的結果情況的通知詳情</li>
</ol>
<p>8A. 附加於股份的投票權</p>
<table>
<thead>
<tr>
<th></th>
<th></th>
<th></th>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>股份類別/類型 ISIN 代碼（如可能）</td>
<td>直接投票權數量（DTR5.1）</td>
<td>間接投票權數量（DTR5.2.1）</td>
<td>直接投票權的百分比（DTR5.1）</td>
<td>間接投票權的百分比（DTR5.2.1）</td>
</tr>
<tr>
<td>GB00BQVXM815</td>
<td>211976</td>
<td>187502</td>
<td>3.582000</td>
<td>3.168640</td>
</tr>
<tr>
<td>小計 8.A</td>
<td>399478</td>
<td>6.750640%</td>
<td></td>
<td></td>
</tr>
</tbody>
</table>
<p>8B1. 根據 (DTR5.3.1R.(1) (a)) 的金融工具</p>
<table>
<thead>
<tr>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>金融工具類型</td>
<td>小計 8.B1</td>
</tr>
<tr>
<td>到期日</td>
<td></td>
</tr>
<tr>
<td>行使/轉換期限</td>
<td></td>
</tr>
<tr>
<td>如果行使/轉換該工具可獲得的投票權數量</td>
<td></td>
</tr>
<tr>
<td>投票權的百分比</td>
<td></td>
</tr>
</tbody>
</table>
<p>8B2. 根據 (DTR5.3.1R.(1) (b)) 具有類似經濟效果的金融工具</p>
<table>
<thead>
<tr>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>金融工具類型</td>
<td>小計 8.B2</td>
</tr>
<tr>
<td>到期日</td>
<td></td>
</tr>
<tr>
<td>行使/轉換期限</td>
<td></td>
</tr>
<tr>
<td>實物或現金結算</td>
<td></td>
</tr>
<tr>
<td>投票權數量</td>
<td></td>
</tr>
<tr>
<td>投票權的百分比</td>
<td></td>
</tr>
</tbody>
</table>
<ol>
<li>關於受通知義務約束的個人的信息</li>
</ol>
<ol>
<li>通過最終控制自然人或法律實體有效持有投票權和/或金融工具的控制企業的完整鏈條（如有必要請添加額外行）</li>
</ol>
<table>
<thead>
<tr>
<th></th>
<th></th>
<th></th>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>最終控制人</td>
<td>控制企業名稱</td>
<td>如果等於或高於可通知閾值的投票權百分比</td>
<td>如果等於或高於可通知閾值的通過金融工具的投票權百分比</td>
<td>如果等於或高於可通知閾值的兩者總和</td>
</tr>
<tr>
<td>David Smith</td>
<td></td>
<td>6.750360</td>
<td></td>
<td>6.750360%</td>
</tr>
<tr>
<td>David Smith</td>
<td>GHC Property Services Limited</td>
<td>2.464300</td>
<td></td>
<td>2.464300%</td>
</tr>
<tr>
<td>David Smith</td>
<td>HBP Systems Limited</td>
<td>0.275400</td>
<td></td>
<td>0.275400%</td>
</tr>
<tr>
<td>David Smith</td>
<td>Kamarin Computers Limited</td>
<td>0.275400</td>
<td></td>
<td>0.275400%</td>
</tr>
<tr>
<td>David Smith</td>
<td>HBP Monpellier Limited</td>
<td>0.275400</td>
<td></td>
<td>0.275400%</td>
</tr>
<tr>
<td>David Smith</td>
<td>Copier Systems Limited</td>
<td>0.275400</td>
<td></td>
<td>0.275400%</td>
</tr>
</tbody>
</table>
<ol>
<li>在代理投票的情況下</li>
</ol>
<p>代理持有人的姓名</p>
<p>持有的投票權數量和百分比</p>
<p>持有投票權的日期</p>
<ol>
<li>附加信息</li>
</ol>
<p>對之前通知的更正</p>
<ol>
<li>完成日期</li>
</ol>
<p>2025 年 12 月 5 日</p>
<ol>
<li>完成地點</li>
</ol>
<p>英格蘭赫爾</p>
<p>此信息由 RNS 提供，倫敦證券交易所的新聞服務。RNS 獲得金融行為監管局的批准，作為英國的主要信息提供者。有關使用和分發此信息的條款和條件可能適用。如需更多信息，請聯繫 rns@lseg.com 或訪問 www.rns.com。</p>
<p>RNS 可能會使用您的 IP 地址以確認遵守條款和條件，分析您與本通信中包含的信息的互動，並在我們的商業服務中以匿名方式與他人共享此分析。如需更多關於 RNS 和倫敦證券交易所如何使用您提供的個人數據的信息，請參見我們的隱私政策。結束 HOLUWOURVWUURAA</p>

<p>Hemogenyx Pharmaceuticals PLC 宣佈了主要持股的變更。David John Smith 的投票權已從之前的 5.163200% 增加至 6.750640%。該通知是在投票權的收購或處置後發佈的，閾值在 2025 年 11 月 24 日被突破。通知中包括了多個受控企業及其各自的投票權百分比的詳細信息</p>

<p>RNS Number : 6849K Hemogenyx Pharmaceuticals PLC 08 December 2025</p>
<div class="lb-trans"><p>RNS 編號：6849K Hemogenyx Pharmaceuticals PLC2025 年 12 月 8 日</p>
</div><p>TR-1: Standard form for notification of major holdings</p>
<div class="lb-trans"><p>TR-1：主要持股通知的標準表格</p>
</div><p>1. Issuer Details</p>
<div class="lb-trans"><ol>
<li>發行人詳情</li>
</ol>
</div><p>ISIN</p>
<div class="lb-trans"><p>ISIN</p>
</div><p>GB00BQVXM815</p>
<div class="lb-trans"><p>GB00BQVXM815</p>
</div><p>Issuer Name</p>
<div class="lb-trans"><p>發行人名稱</p>
</div><p>HEMOGENYX PHARMACEUTICALS PLC</p>
<div class="lb-trans"><p>HEMOGENYX PHARMACEUTICALS PLC</p>
</div><p>UK or Non-UK Issuer</p>
<div class="lb-trans"><p>英國或非英國發行人</p>
</div><p>UK</p>
<div class="lb-trans"><p>英國</p>
</div><p>2. Reason for Notification</p>
<div class="lb-trans"><ol>
<li>通知原因</li>
</ol>
</div><p>An acquisition or disposal of voting rights</p>
<div class="lb-trans"><p>投票權的收購或處置</p>
</div><p>3. Details of person subject to the notification obligation</p>
<div class="lb-trans"><ol>
<li>受通知義務約束的個人詳情</li>
</ol>
</div><p>Name</p>
<div class="lb-trans"><p>姓名</p>
</div><p>David John Smith</p>
<div class="lb-trans"><p>David John Smith</p>
</div><p>City of registered office (if applicable)</p>
<div class="lb-trans"><p>註冊辦公室所在城市（如適用）</p>
</div><p>grimsby</p>
<div class="lb-trans"><p>格里姆斯比</p>
</div><p>Country of registered office (if applicable)</p>
<div class="lb-trans"><p>註冊辦公室所在國家（如適用）</p>
</div><p>United Kingdom</p>
<div class="lb-trans"><p>英國</p>
</div><p>4. Details of the shareholder</p>
<div class="lb-trans"><ol>
<li>股東詳情</li>
</ol>
</div><table>
<thead>
<tr>
<th></th>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>Name</td>
<td>City of registered office</td>
<td>Country of registered office</td>
</tr>
<tr>
<td>GHC Property Services Limited</td>
<td>Grimsby</td>
<td>England</td>
</tr>
<tr>
<td>Copier Systems Limited</td>
<td>Scunthorpe</td>
<td>England</td>
</tr>
<tr>
<td>HBP Monpellier Limited</td>
<td>Carlisle</td>
<td>England</td>
</tr>
<tr>
<td>Kamarin Computers Limited</td>
<td>Scunthorpe</td>
<td>England</td>
</tr>
<tr>
<td>HBP Systems Limited</td>
<td>Scunthorpe</td>
<td>England</td>
</tr>
<tr>
<td>Transact Nominees Limited</td>
<td>London</td>
<td>England</td>
</tr>
<tr>
<td>Interactive Investor Services Nominees Limited</td>
<td>Manchester</td>
<td>England</td>
</tr>
</tbody>
</table>
<div class="lb-trans"><table>
<thead>
<tr>
<th></th>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>名稱</td>
<td>註冊辦公室所在城市</td>
<td>註冊辦公室所在國家</td>
</tr>
<tr>
<td>GHC Property Services Limited</td>
<td>格里姆斯比</td>
<td>英格蘭</td>
</tr>
<tr>
<td>Copier Systems Limited</td>
<td>斯肯索普</td>
<td>英格蘭</td>
</tr>
<tr>
<td>HBP Monpellier Limited</td>
<td>卡萊爾</td>
<td>英格蘭</td>
</tr>
<tr>
<td>Kamarin Computers Limited</td>
<td>斯肯索普</td>
<td>英格蘭</td>
</tr>
<tr>
<td>HBP Systems Limited</td>
<td>斯肯索普</td>
<td>英格蘭</td>
</tr>
<tr>
<td>Transact Nominees Limited</td>
<td>倫敦</td>
<td>英格蘭</td>
</tr>
<tr>
<td>Interactive Investor Services Nominees Limited</td>
<td>曼徹斯特</td>
<td>英格蘭</td>
</tr>
</tbody>
</table>
</div><p>5. Date on which the threshold was crossed or reached</p>
<div class="lb-trans"><ol>
<li>超過或達到閾值的日期</li>
</ol>
</div><p>24-Nov-2025</p>
<div class="lb-trans"><p>2025 年 11 月 24 日</p>
</div><p>6. Date on which Issuer notified</p>
<div class="lb-trans"><ol>
<li>發行人通知的日期</li>
</ol>
</div><p>24-Nov-2025</p>
<div class="lb-trans"><p>2025 年 11 月 24 日</p>
</div><p>7. Total positions of person(s) subject to the notification obligation</p>
<div class="lb-trans"><ol>
<li>受通知義務約束的個人的總持倉</li>
</ol>
</div><table>
<thead>
<tr>
<th></th>
<th></th>
<th></th>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td></td>
<td>% of voting rights attached to shares (total of 8.A)</td>
<td>% of voting rights through financial instruments (total of 8.B 1 + 8.B 2)</td>
<td>Total of both in % (8.A + 8.B)</td>
<td>Total number of voting rights held in issuer</td>
</tr>
<tr>
<td>Resulting situation on the date on which threshold was crossed or reached</td>
<td>6.750640</td>
<td>0.000000</td>
<td>6.750640</td>
<td>399478</td>
</tr>
<tr>
<td>Position of previous notification (if applicable)</td>
<td>5.163200</td>
<td>0.000000</td>
<td>5.163200</td>
<td></td>
</tr>
</tbody>
</table>
<div class="lb-trans"><table>
<thead>
<tr>
<th></th>
<th></th>
<th></th>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td></td>
<td>附加於股份的投票權百分比（8.A 總計）</td>
<td>通過金融工具的投票權百分比（8.B 1 + 8.B 2 總計）</td>
<td>兩者總和的百分比（8.A + 8.B）</td>
<td>發行人持有的投票權總數</td>
</tr>
<tr>
<td>超過或達到閾值時的結果情況</td>
<td>6.750640</td>
<td>0.000000</td>
<td>6.750640</td>
<td>399478</td>
</tr>
<tr>
<td>之前通知的持倉情況（如適用）</td>
<td>5.163200</td>
<td>0.000000</td>
<td>5.163200</td>
<td></td>
</tr>
</tbody>
</table>
</div><p>8. Notified details of the resulting situation on the date on which the threshold was crossed or reached</p>
<div class="lb-trans"><ol>
<li>超過或達到閾值時的結果情況的通知詳情</li>
</ol>
</div><p>8A. Voting rights attached to shares</p>
<div class="lb-trans"><p>8A. 附加於股份的投票權</p>
</div><table>
<thead>
<tr>
<th></th>
<th></th>
<th></th>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>Class/Type of shares ISIN code(if possible)</td>
<td>Number of direct voting rights (DTR5.1)</td>
<td>Number of indirect voting rights (DTR5.2.1)</td>
<td>% of direct voting rights (DTR5.1)</td>
<td>% of indirect voting rights (DTR5.2.1)</td>
</tr>
<tr>
<td>GB00BQVXM815</td>
<td>211976</td>
<td>187502</td>
<td>3.582000</td>
<td>3.168640</td>
</tr>
<tr>
<td>Sub Total 8.A</td>
<td>399478</td>
<td>6.750640%</td>
<td></td>
<td></td>
</tr>
</tbody>
</table>
<div class="lb-trans"><table>
<thead>
<tr>
<th></th>
<th></th>
<th></th>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>股份類別/類型 ISIN 代碼（如可能）</td>
<td>直接投票權數量（DTR5.1）</td>
<td>間接投票權數量（DTR5.2.1）</td>
<td>直接投票權的百分比（DTR5.1）</td>
<td>間接投票權的百分比（DTR5.2.1）</td>
</tr>
<tr>
<td>GB00BQVXM815</td>
<td>211976</td>
<td>187502</td>
<td>3.582000</td>
<td>3.168640</td>
</tr>
<tr>
<td>小計 8.A</td>
<td>399478</td>
<td>6.750640%</td>
<td></td>
<td></td>
</tr>
</tbody>
</table>
</div><p>8B1. Financial Instruments according to (DTR5.3.1R.(1) (a))</p>
<div class="lb-trans"><p>8B1. 根據 (DTR5.3.1R.(1) (a)) 的金融工具</p>
</div><table>
<thead>
<tr>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>Type of financial instrument</td>
<td>Sub Total 8.B1</td>
</tr>
<tr>
<td>Expiration date</td>
<td></td>
</tr>
<tr>
<td>Exercise/conversion period</td>
<td></td>
</tr>
<tr>
<td>Number of voting rights that may be acquired if the instrument is exercised/converted</td>
<td></td>
</tr>
<tr>
<td>% of voting rights</td>
<td></td>
</tr>
</tbody>
</table>
<div class="lb-trans"><table>
<thead>
<tr>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>金融工具類型</td>
<td>小計 8.B1</td>
</tr>
<tr>
<td>到期日</td>
<td></td>
</tr>
<tr>
<td>行使/轉換期限</td>
<td></td>
</tr>
<tr>
<td>如果行使/轉換該工具可獲得的投票權數量</td>
<td></td>
</tr>
<tr>
<td>投票權的百分比</td>
<td></td>
</tr>
</tbody>
</table>
</div><p>8B2. Financial Instruments with similar economic effect according to (DTR5.3.1R.(1) (b))</p>
<div class="lb-trans"><p>8B2. 根據 (DTR5.3.1R.(1) (b)) 具有類似經濟效果的金融工具</p>
</div><table>
<thead>
<tr>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>Type of financial instrument</td>
<td>Sub Total 8.B2</td>
</tr>
<tr>
<td>Expiration date</td>
<td></td>
</tr>
<tr>
<td>Exercise/conversion period</td>
<td></td>
</tr>
<tr>
<td>Physical or cash settlement</td>
<td></td>
</tr>
<tr>
<td>Number of voting rights</td>
<td></td>
</tr>
<tr>
<td>% of voting rights</td>
<td></td>
</tr>
</tbody>
</table>
<div class="lb-trans"><table>
<thead>
<tr>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>金融工具類型</td>
<td>小計 8.B2</td>
</tr>
<tr>
<td>到期日</td>
<td></td>
</tr>
<tr>
<td>行使/轉換期限</td>
<td></td>
</tr>
<tr>
<td>實物或現金結算</td>
<td></td>
</tr>
<tr>
<td>投票權數量</td>
<td></td>
</tr>
<tr>
<td>投票權的百分比</td>
<td></td>
</tr>
</tbody>
</table>
</div><p>9. Information in relation to the person subject to the notification obligation</p>
<div class="lb-trans"><ol>
<li>關於受通知義務約束的個人的信息</li>
</ol>
</div><p>2. Full chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held starting with the ultimate controlling natural person or legal entities (please add additional rows as necessary)</p>
<div class="lb-trans"><ol>
<li>通過最終控制自然人或法律實體有效持有投票權和/或金融工具的控制企業的完整鏈條（如有必要請添加額外行）</li>
</ol>
</div><table>
<thead>
<tr>
<th></th>
<th></th>
<th></th>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>Ultimate controlling person</td>
<td>Name of controlled undertaking</td>
<td>% of voting rights if it equals or is higher than the notifiable threshold</td>
<td>% of voting rights through financial instruments if it equals or is higher than the notifiable threshold</td>
<td>Total of both if it equals or is higher than the notifiable threshold</td>
</tr>
<tr>
<td>David Smith</td>
<td></td>
<td>6.750360</td>
<td></td>
<td>6.750360%</td>
</tr>
<tr>
<td>David Smith</td>
<td>GHC Property Services Limited</td>
<td>2.464300</td>
<td></td>
<td>2.464300%</td>
</tr>
<tr>
<td>David Smith</td>
<td>HBP Systems Limited</td>
<td>0.275400</td>
<td></td>
<td>0.275400%</td>
</tr>
<tr>
<td>David Smith</td>
<td>Kamarin Computers Limited</td>
<td>0.275400</td>
<td></td>
<td>0.275400%</td>
</tr>
<tr>
<td>David Smith</td>
<td>HBP Monpellier Limited</td>
<td>0.275400</td>
<td></td>
<td>0.275400%</td>
</tr>
<tr>
<td>David Smith</td>
<td>Copier Systems Limited</td>
<td>0.275400</td>
<td></td>
<td>0.275400%</td>
</tr>
</tbody>
</table>
<div class="lb-trans"><table>
<thead>
<tr>
<th></th>
<th></th>
<th></th>
<th></th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<td>最終控制人</td>
<td>控制企業名稱</td>
<td>如果等於或高於可通知閾值的投票權百分比</td>
<td>如果等於或高於可通知閾值的通過金融工具的投票權百分比</td>
<td>如果等於或高於可通知閾值的兩者總和</td>
</tr>
<tr>
<td>David Smith</td>
<td></td>
<td>6.750360</td>
<td></td>
<td>6.750360%</td>
</tr>
<tr>
<td>David Smith</td>
<td>GHC Property Services Limited</td>
<td>2.464300</td>
<td></td>
<td>2.464300%</td>
</tr>
<tr>
<td>David Smith</td>
<td>HBP Systems Limited</td>
<td>0.275400</td>
<td></td>
<td>0.275400%</td>
</tr>
<tr>
<td>David Smith</td>
<td>Kamarin Computers Limited</td>
<td>0.275400</td>
<td></td>
<td>0.275400%</td>
</tr>
<tr>
<td>David Smith</td>
<td>HBP Monpellier Limited</td>
<td>0.275400</td>
<td></td>
<td>0.275400%</td>
</tr>
<tr>
<td>David Smith</td>
<td>Copier Systems Limited</td>
<td>0.275400</td>
<td></td>
<td>0.275400%</td>
</tr>
</tbody>
</table>
</div><p>10. In case of proxy voting</p>
<div class="lb-trans"><ol>
<li>在代理投票的情況下</li>
</ol>
</div><p>Name of the proxy holder</p>
<div class="lb-trans"><p>代理持有人的姓名</p>
</div><p>The number and % of voting rights held</p>
<div class="lb-trans"><p>持有的投票權數量和百分比</p>
</div><p>The date until which the voting rights will be held</p>
<div class="lb-trans"><p>持有投票權的日期</p>
</div><p>11. Additional Information</p>
<div class="lb-trans"><ol>
<li>附加信息</li>
</ol>
</div><p>Correction of a previous notification</p>
<div class="lb-trans"><p>對之前通知的更正</p>
</div><p>12. Date of Completion</p>
<div class="lb-trans"><ol>
<li>完成日期</li>
</ol>
</div><p>05-Dec-2025</p>
<div class="lb-trans"><p>2025 年 12 月 5 日</p>
</div><p>13. Place Of Completion</p>
<div class="lb-trans"><ol>
<li>完成地點</li>
</ol>
</div><p>Hull, England</p>
<div class="lb-trans"><p>英格蘭赫爾</p>
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