<div id="readability-page-1"> Life expectancy continues to rise, but the number of healthy life years is increasing at a much slower pace. Solving this imbalance is considered a key growth driver in healthcare and creates attractive investment opportunities. Bellevue Asset Management has embedded longevity in its healthcare strategies. Healthspan is the key economic variable of longevity. Between 2000 and 2019, global life expectancy increased by 6,5 years, while healthy life expectancy rose by only 5,4 years – the gap now averages 9,6 years and continues to widen. These additional years are often characterized by chronic diseases and account for a significant share of healthcare costs. Key drivers include cardiometabolic diseases (e.g. diabetes, cardiovascular diseases), neurodegeneration (e.g. Alzheimer’s or Parkinson’s) and age-related functional decline (e.g. muscle loss or reduced mobility). Trends in Life Expectancy vs Health-Adjusted Expectancy <img src="https://imageproxy.pbkrs.com/https://www.finews.asia/images/advertorials/2026/Bellevue_Mai_Grafik_Mai.jpg?x-oss-process=image/auto-orient,1/interlace,1/resize,w_1440,h_1440/quality,q_95/format,jpg" width="646" height="388" original-src="https://imageproxy.pbkrs.com/https://www.finews.asia/images/advertorials/2026/Bellevue_Mai_Grafik_Mai.jpg"/> Source: Institute for Health Metrics and Evaluation (IHME). Global Burden of Disease Study 2019 (GBD 2019) Results. «The economic logic is clear: value is created where this gap is reduced – not where lifespan is extended in isolation», says Marcel Fritsch, Head Healthcare Funds &amp; Mandates at Bellevue Asset Management. This is where longevity emerges as an investment theme: new approaches in prevention and early detection, as well as solutions that slow disease progression, reduce hospitalizations and preserve independence. Three Key Value Drivers Create Investment Opportunities Value creation along the longevity theme follows clearly identifiable mechanisms and can already be translated into concrete business models. What matters is not technological innovation per se, but its ability to measurably improve clinical outcomes while sustainably transforming the cost structure of the healthcare system. 1. Prevention and early detection through digital health monitoring Digital monitoring solutions shift diagnosis and intervention significantly earlier by continuously capturing physiological data and identifying early risk signals – from wearables such as Oura or Apple to clinically validated systems such as CGM from Abbott and Dexcom or cardiology patches from iRhythm. The value arises from preventing acute events, delaying the progression of chronic diseases, and reducing cost-intensive escalations, while integrated data ecosystems simultaneously build structural competitive advantages. 2. Minimally invasive interventions to enhance quality of life Minimally invasive and robot-assisted procedures shift the focus from repair to preserving mobility and autonomy by enabling more precise, less invasive and earlier interventions in the disease pathway – for example through systems from Stryker or Intuitive Surgical. The economic benefit lies in shorter recovery times, lower complication rates, fewer follow-up procedures and a growing shift to outpatient care. 3. Targeted treatment of age-related diseases Advances in pharmacotherapy increasingly address cross-disease biological mechanisms rather than isolated indications – particularly along the cardiometabolic axis (Novo Nordisk, Eli Lilly, Amgen) as well as in neurodegeneration (Biogen, Eisai, Eli Lilly) and oncology (Merck &amp; Co., AstraZeneca). These therapies slow disease progression, reduce mortality and extend the period during which people can live independently. Investing in Longevity: Bellevue Healthcare ETF Investment opportunities are primarily found where costly phases of disease can be shortened. The focus is therefore on companies that measurably slow disease progression, improve efficiency in care delivery and develop scalable solutions across prevention, diagnostics and systemic therapies. This is where the Bellevue Healthcare ETF comes in: It combines Bellevue’s long-standing healthcare expertise with the format of an actively managed UCITS ETF. Approximately 80 percent of the fund is invested in companies with direct exposure along the longevity value chain (treatment of cardiovascular, oncological, metabolic, musculoskeletal, neurodegenerative or sensory diseases), with a further approximately 10–20 percent invested in companies with indirect exposure (including managed care, distributors, life science tools, CDMOs and healthcare IT). For investors seeking to benefit from the longevity trend, the following advantages arise: <ul> <li>Active approach with a focus on 50–100 high-conviction stocks</li> <li>Exploitation of market inefficiencies through selective stock picking</li> <li>Fundamental bottom-up selection with clearly defined value drivers</li> <li>High liquidity, transparency, cost efficiency (TER 0,55 percent) and daily tradability</li> <li>More than 30 years of specialized healthcare expertise</li> <li>With its clear focus on extending healthspan, the Bellevue Healthcare ETF targets one of the most sustainable growth trends in the global healthcare market – directly linking medical progress with economic value.</li> </ul> Learn more about our investment solution here. Contact Bellevue Asset Management AG, Theaterstrasse 12, CH-8001 Zurich, Tanja Chicherio, Tel. +41 44 267 67 07, This email address is being protected from spambots. You need JavaScript enabled to view it., www.bellevue.ch Bellevue – Excellence in Specialty Investments Bellevue is a specialized asset manager listed on the SIX Swiss Exchange with core competencies covering healthcare strategies, entrepreneur strategies, alternative and traditional investment strategies. Established in 1993, Bellevue, a House of Investment Ideas staffed by 75 professionals, generates attractive investment returns and creates value added for clients and shareholders alike. Bellevue managed 5,3 bn francs in assets as of December 31, 2025. <hr/> Disclaimer This marketing communication is issued by Bellevue Asset Management AG, an authorized asset manager supervised by the Swiss Financial Market Supervisory Authority (FINMA), acting as investment manager of the fund. The prospectus, fund documents, Key Information Documents (KIDs) in English and German, and further information can be obtained free of charge from Bellevue Asset Management AG, Theaterstrasse 12, CH-8001 Zurich, or at www.bellevue.ch. This document is not intended for distribution to any person in a jurisdiction where such distribution would be unlawful. In particular, it is not intended for US persons as defined in Regulation S under the US Securities Act of 1933, as amended. This document does not constitute an offer or solicitation to buy or sell any financial instruments. The information reflects the views at the time of publication and may change without notice. It does not take into account the specific investment objectives, financial situation, or needs of any individual investor. Tax treatment depends on personal circumstances and may be subject to change. Investors are advised to assess the suitability of the investment and seek professional advice before making an investment decision. All investments involve risks, including currency risks that may affect returns. Past performance is not a reliable indicator of future results. Performance figures do not account for commissions or fees associated with subscriptions, redemptions, or trading. Any reference to a specific company does not constitute a recommendation to buy, sell, hold, or directly invest in that company. ETF shares purchased on the secondary market cannot usually be redeemed directly from the fund. Investors must buy and sell through an intermediary and may incur trading fees or receive less than the NAV. The Summary of Investor Rights is available in English at: https://www.waystone.com/wp-content/uploads/Policy/IE/Waystone-Management-Company-(IE)-Limited/Waystone-Management-Company-(IE)-Limited-Summary-of-Investor-Rights.pdf. The Management Company may decide to terminate marketing arrangements for the fund under Article 93a of Directive 2009/65/EC. </div>

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The rise in life expectancy is outpacing the increase in healthy life years, creating a significant gap that presents investment opportunities in healthcare. Bellevue Asset Management emphasizes longevity in its strategies, focusing on healthspan as a key economic variable. Key investment drivers include prevention through digital health monitoring, minimally invasive interventions, and targeted treatments for age-related diseases. The Bellevue Healthcare ETF targets companies that improve clinical outcomes and reduce healthcare costs, aiming to capitalize on the longevity trend in the healthcare market.

Longevity: Where Medical Progress Creates Economic Value