<div id="readability-page-1"><div> <h2>Key Points</h2><ul><li>Agios shares rose after strong earnings and Aqvesme's commercial launch.</li><li>Mitapivat faces competition from Novo Nordisk's etavopivat in the treatment of sickle cell disease.</li><li>Key pipeline updates and catalysts are expected in 2026, especially for tebapivat.</li><li>10 stocks we like better than Novo Nordisk ›</li></ul>Shares in Agios Pharmaceuticals (NASDAQ: AGIO) rose by 11.2% this week, putting the stock into positive territory for the year. The move comes after a well-received first-quarter earnings report that showed strong progress in Aqvesme's U.S. commercial launch. Management also provided an update on the progress of its pipeline, including mitapivat for sickle cell disease (SCD) and tebapivat for Lower-Risk Myelodysplastic Syndromes (MDS) and SCD.<h2>Agios has a busy 2026 ahead</h2>The pharmaceutical company already has mitapivat approved to treat hemolytic anemia in adults with Pyruvate Kinase (PK) deficiency under the brand name Pyrukynd. It also has mitapivat, which was more recently approved in the U.S. to treat adult thalassemia under the brand name Aqvesme, and the addition of Aqvesme sales (the first quarter of full sales) helped sales grow to $20.7 million from just $8.7 million in the same quarter of 2025. Management expects &#34;very strong demand&#34; for Aqvesme in the coming quarters. Will AI create the world's first trillionaire? Our team just released a report on the one little-known company, called an &#34;Indispensable Monopoly&#34; providing the critical technology Nvidia and Intel both need. Continue »<h2>Where next for Agios Pharmaceuticals</h2>As readers already know, the company recently suffered a setback when a rival developer of a pyruvate kinase-R (PKR) activator, Novo Nordisk, reported top-line results from a trial indicating that its drug, etavopivat, was superior to mitapivat in treating SCD. In a nutshell, etavopivat achieved both of its primary endpoints in SCD, but mitapivat failed to meet one of them: reducing the annualized rate of pain crisis events. It's unclear what the market potential for mitapivat (SCD) will be. Still, management confirmed it was aligned with the Food and Drug Administration (FDA) &#34;on a path toward U.S. accelerated approval for mitapivat in sickle cell disease&#34; with filing expected in the second quarter. <img src="https://imageproxy.pbkrs.com/https://g.foolcdn.com/image//query-dXJsPWh0dHBzOi8vZy5mb29sY2RuLmNvbS9lZGl0b3JpYWwvaW1hZ2VzLzg2ODQ2Ni9zdG9jay1pbnZlc3Rvci1sYXB0b3AuanBnJnc9NzAw?x-oss-process=image/auto-orient,1/interlace,1/resize,w_1440,h_1440/quality,q_95/format,jpg" width="700" height="467" original-src="https://imageproxy.pbkrs.com/https://g.foolcdn.com/image//query-dXJsPWh0dHBzOi8vZy5mb29sY2RuLmNvbS9lZGl0b3JpYWwvaW1hZ2VzLzg2ODQ2Ni9zdG9jay1pbnZlc3Rvci1sYXB0b3AuanBnJnc9NzAw"/>Image source: Getty Images. That said, investors probably have higher hopes for its next-generation PKR, tebapivat, which management confirmed will have Phase 2 top-line results available in MDS in the first half of 2026, and then SCD in the second half of 2026. All told, a good start for Aqvesme, progress on mitapivat approval in SCD, and the hope of some positive news on tebapivat make for an exciting year for the company. <h2>Should you buy stock in Novo Nordisk right now?</h2> Before you buy stock in Novo Nordisk, consider this: The Motley Fool Stock Advisor analyst team just identified what they believe are the 10 best stocks for investors to buy now… and Novo Nordisk wasn’t one of them. The 10 stocks that made the cut could produce monster returns in the coming years. Consider when Netflix made this list on December 17, 2004... if you invested $1,000 at the time of our recommendation, you’d have $504,832!* Or when Nvidia made this list on April 15, 2005... if you invested $1,000 at the time of our recommendation, you’d have $1,223,471!* Now, it’s worth noting Stock Advisor’s total average return is 971% — a market-crushing outperformance compared to 202% for the S&amp;P 500. Don't miss the latest top 10 list, available with Stock Advisor, and join an investing community built by individual investors for individual investors. See the 10 stocks » *Stock Advisor returns as of May 2, 2026. Lee Samaha has no position in any of the stocks mentioned. The Motley Fool recommends Novo Nordisk. The Motley Fool has a disclosure policy. The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc. </div></div>

AGIO

Agios Pharmaceuticals' shares surged 11.2% this week following strong earnings and the U.S. launch of Aqvesme. The company faces competition from Novo Nordisk's etavopivat in treating sickle cell disease, but expects significant pipeline updates in 2026, particularly for tebapivat. Agios has seen sales grow to $20.7 million, driven by Aqvesme's performance. Despite challenges with mitapivat's competition, management is optimistic about future approvals and demand for their products.

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Here's Why Shares in Agios Pharmaceuticals Soared This Week (And What to Expect Next in 2026)