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Health Rounds: How obesity leads to uncontrolled inflammation discovered

Researchers have discovered the pathway linking obesity to uncontrolled inflammation, which can lead to serious health issues like diabetes and liver disease. The study highlights the role of the NLRP3 protein complex and the enzyme SAMHD1 in this process. Additionally, new research suggests that messenger RNA could be used to improve embryo attachment in the uterus, potentially offering new treatments for infertility. This involves using lipid nanoparticles to deliver genetic material that enhances the endometrium's ability to support embryo implantation.

Industry ETFs in the U.S. stock market opened almost entirely in decline, with the Biotechnology Index ETF, Consumer Discretionary ETF, and Global Technology Stocks Index ETF down by as much as 2.29%. The Internet Stocks Index ETF, Technology Sector ETF, and Semiconductor ETF fell by as much as 1.82%, while the Energy Sector ETF rose by 0.55%

Pre-market hot trades in US stocks: Galaxy Payroll pre-market down 15.61%; United Microelectronics pre-market up 14.09%

Galaxy Payroll pre-market down 15.61%; United Microelectronics pre-market up 14.09%; INVO Fertility pre-market up 405.91%; Icon Energy pre-market up 140.21%; RAPT Therapeutics pre-market up 63.42%

Ascletis chooses ASC37, a once-monthly subcutaneously administered peptide agonist, with 17-day half-life, for clinical development.

ASC37 has shown to have an average observed half-life of around 17 days in head-to-head non-human primate studies, which is 7 times longer than retatrutide. This indicates its potential for once-monthly subcutaneous dosing in humans. Additionally, ASC37 exhibited approximately 5-, 4-, and 4-fold greater in vitro activity compared to other substances.

2026 AI Agent Economic Outlook: Reshaping AI Identity and the Flow of Network Value

The 2026 AI Agent Economic Outlook predicts a significant shift from generative AI to agent action capabilities, marking the establishment of the "AI Agent Economy." Key trends include a new research paradigm of "Agent-Wrapping-Agent," a revolution in financial infrastructure from KYC to KYA, and economic model reconstruction to address hidden tax crises in open networks. The report highlights advancements in AI reasoning abilities, enabling complex research tasks and interdisciplinary exploration, exemplified by breakthroughs in protein design and fluid dynamics. The AWA architecture enhances research workflows through multi-agent collaboration and self-improvement mechanisms.